Vnitr Lek 2025, 71(5):E1-E5

Myostatin and irisin in predicting the outcomes of patients with systemic inflammation

Otakar Pšenička, Zuzana Kršáková, Jarmila Křížová
3. interní klinika VFN a 1. LF UK, Praha

Background: Systemic inflammatory response syndrome (SIRS) is associated with rapid development of myopathy. Skeletal muscles produce myokines, which may contribute to muscle weakness. The aim of this study is to determine the potential effect of selected myokines in SIRS on the length of the hospitalization of probands.

Methodology: Levels of myostatin and irisin, selected, laboratory and muscle parameters were recorded upon admission and at the day 10 of hospital stay. Control group consists of healthy individuals with BMI 18,5-29,9.

Results: Myostatin levels were higher in probands than in controls and there was a significant correlation between myostatin and inflammatory markers. Irisin levels were higher in women and correlated with BMI. Both myostatin and irisin levels correlated with change of ultrasound measured femoral muscle thickness.

Conclusions: A trend towards longer length of hospital stay in patients with higher myokine levels was observed. Myostatin and irisin can be useful markers in predicting the outcome of patients with SIRS.

Keywords: myokines, SIRS, critical illness myopathy, femoral muscle ultrasound.

Accepted: August 26, 2025; Published: September 18, 2025  Show citation

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Pšenička O, Kršáková Z, Křížová J. Myostatin and irisin in predicting the outcomes of patients with systemic inflammation. Vnitr Lek. 2025;71(5):E1-5.
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