Hormonal therapy in transsexual patients - editorial

Karel Starý

Vnitr Lek 2015, 61(3):189  

The most recent aspects of diagnosis and therapy of hyponatraemia - editorial

Otto Schück, Jiří Kříž, Miroslava Horáčková

Vnitr Lek 2015, 61(3):190-192  

Non-celiac gluten sensitivity - editorial

Pavel Kohout

Vnitr Lek 2015, 61(3):193-194  

Non-celiac gluten sensitivity - editorial

Michal Šenkyřík, Jitka Prokešová

Vnitr Lek 2015, 61(3):195-196  

Our experience with hormonal therapy in transsexual patients

Vladimír Weiss, Petr Weiss, Hana Fifková

Vnitr Lek 2015, 61(3):197-201  

Hormonal therapy in transsexual patients (TS) includes sexagens administration: androgens in female-to-male transsexual patients (FtM) and oestrogens and antiandrogens in male-to-female transsexual patients (MtF). Duration of hormonal therapy should continue at least 1 year before gender reassignment surgery. Hormonal therapy supresses former gender and induces partially new gender changes. Hormonal therapy continues subsequently after surgery during life. Hormonal therapy in MtF TS includes oestrogens and antiandrogens application. In very young persons in both groups blocking gonadoliberin analogues can be used. In FtM TS testosterone onself is given...

Does body height affect the severity of chronic venous disease in lower extremities?

Jiří Spáčil

Vnitr Lek 2015, 61(3):202-206  

Introduction:The effect of obesity on chronic venous disease has been known. The effect of body height has not been studied until now, although venous pressure is clearly influenced by hydrostatic pressure in the vertical position. Methods:We have examined 1 026 lower extremities in 124 men and 392 women with suspected chronic venous disease. Their clinical condition was evaluated using CEAP classification. Duplex sonography was used to exclude deep venous occlusion and to evaluate any present reflux. Venous functions were evaluated based on venous pump performance during exercise and according to venous refilling time. Results:We...

New ESC guidelines on the diagnosis and management of acute pulmonary embolism

Jiří Widimský sr, Michael Aschermann

Vnitr Lek 2015, 61(3):236-243  

Pelvic venous congestion syndrome - diagnosis and management. Guidelines of the Angiology Section of Slovak Medical Chamber (2015)

Peter Gavorník, Karol Holomáň, Ľudovít Gašpar, Andrej Dukát, Andrea Komorníková, Emil Gavorník

Vnitr Lek 2015, 61(3):244-250  

Pelvic congestion syndrome: chronic symptoms, which may include pelvic pain, perineal heaviness, urgency of micturition, and post-coital pain, caused by ovarian and/or pelvic vein reflux and/or obstruction, and which may be associated with vulvar, perineal, and/or lower extremity varices. The VEIN-TERM consensus document was developed by a transatlantic interdisciplinary faculty of experts under the auspices of the American Venous Forum (AVF), the European Venous Forum (EVF), the International Union of Phlebology (IUP), the American College of Phlebology (ACP), and the International Union of Angiology (IUA). It provides recommendations for fundamental...

Experiences with biosimilar drugs in therapy

Jaroslav Škvor

Vnitr Lek 2015, 61(3):207-208  

Biosimilar drugs or drugs which are similar to reference biological drugs represent a new treatment option within the biological treatment. They are already the standard biotherapeutics option in some fields of medicine, in others as in diabetology, remain to be evaluated. The article presents the definition of biosimilar drugs and summarizes the therapeutic benefits and attitudes of agencies for drug control in the United States and Europe.

The most recent aspects of diagnosis and therapy of hyponatraemia

Igor Šturdík, Monika Adamcová, Juraj Payer

Vnitr Lek 2015, 61(3):209-218  

Hyponatraemia is the most common electrolyte disbalance in clinical practice, which is associated with increased patients morbidity and mortality. At present the pathophysiology of hyponatraemia is explored in more details, antidiuretic hormone and osmoregulation play the major roles. This article informs about relatively new classification of hyponatraemia for clinical practice based on the severity of clinical symptoms and based on the effective serum osmolality. It also offers diagnostic and treatment guidelines of hyponatraemia, which are based on current recommendations of the world experts and on the evidence based medicine.

Non-celiac gluten sensitivity

Iva Hoffmanová, Daniel Sánchez

Vnitr Lek 2015, 61(3):219-227  

Non-celiac gluten sensitivity has recently been recognized by the scientific community as a part of gluten-related disorders, and is defined as a condition with gastrointestinal and/or extra-intestinal symptoms triggered by gluten ingestion in the absence of celiac disease and wheat allergy. Currently, there is no specific serological marker and non-celiac gluten sensitivity remains a diagnosis of exclusion: testing for celiac disease and wheat allergy must be negative, symptoms must improve with a gluten-free diet, and diagnosis must be confirmed by the gluten challenge. In this article, we discuss current knowledge of pathophysiology, clinical and...

Chronic thromboembolic pulmonary hypertension

Zdeněk Vavera

Vnitr Lek 2015, 61(3):228-235  

In recent years, we have witnessed a growing interest in diseases of pulmonary circulation. It is due to the development of specific drug therapy for pulmonary hypertension (PH), improving the availability and performance of endarterectomy techniques of pulmonary artery. This technique has been established as method of choice for patients with chronic thromboembolic pulmonary hypertension (CTEPH). However, the crucial issue is early indication of treatment, right diagnosis and determination of exact type of pulmonary hypertension. Modern therapeutic approaches provide better prognosis, quality of life and even possibility to cure the patients, especially...

PET-CT documented remission of multicentric Castleman disease after treatment with rituximab: case report and review

Zdeněk Adam, Petr Szturz, Renata Koukalová, Zdeněk Řehák, Luděk Pour, Marta Krejčí, Lenka Šmardová, Michal Eid, Pavlína Volfová, Zdeňka Čermáková, Leoš Křen, Filip Sokol, Ivo Hanke, Eva Michalková, Zdeněk Král, Jiří Mayer

Vnitr Lek 2015, 61(3):251-259  

We describe a case of multicentric Castleman disease with generalized lymphadenopathy and splenomegaly, accompanied by typical B symptoms - loss of 15 kg, fever of non-infectious origin, night sweats, symptoms of anemia. Histological examination of the nodes with the highest accumulation of fluorodeoxyglucose, taken from mediastinum by thoracoscopy, revealed plasmocellular type of Castleman disease. Tests for HIV and human herpesvirus 8 (HHV-8) were negative. Three recurrences of herpes zoster indicating an alteration of immunity preceded the diagnosis of disease. Treatment was initiated with combination of thalidomide, dexamethasone, and cyclophosphamide....

Hypersensitive reaction after application of heparin with activation heparin induced trombocytopenia in initiation of intermittent haemodialysis

Jan Masopust, Jiří Charvát, Dana Mokrá, Ondřej Hloch, Jan Háša

Vnitr Lek 2015, 61(3):260-263  

Our report describes the case of patient with hypersensitive reaction regularly arising early after initiation of haemodialysis. This characteristic reaction with pletoric face coloration, bronchospasm, increase of blood pressure, anxiety and decrease of blood oxygen saturation at the consequence and central cyanosis was regularly present without dependence on type of dialysis membrane, drug premedication or prophylactic flushing haemodialysis system by isotonic natrium chloride solution. Low platelet value and trouble-free haemodialysis realized without heparin showed real cause of patients problem. Resolution of this state was regional citrate anticoagulation...

Roman Herzig. Ischemické cévní mozkové příhody

Zbyněk Kalita

Vnitr Lek 2015, 61(3):279  

Mild hypoglycaemia is common in type 2 diabetic patients treated with insulin analogues in the Czech Republic and the patients are concerned about it: results of a GAPP2™ survey (Global Attitudes of Physicians and Patient)

Martin Prázný

Vnitr Lek 2015, 61(3):269-275  

Objective:Mild hypoglycaemia affects diabetes management, productivity and quality of life of patients. Data are scarce about the incidence of mild hypoglycaemia in daily life of type 2 diabetic patients treated with insulin analogues. The aim was to focus on the incidence of mild hypoglycaemia and its consequences in the international GAPP2™ survey (Global Attitudes of Patient and Physicians) conducted also in the Czech Republic. Methods:The GAPP2 ™ project - Global Attitudes of Patients and Physicians is an international cross-sectional study conducted online via Internet in a questionnaire form dedicated to...

40. Angiologické dny 2015

Karel Roztočil

Vnitr Lek 2015, 61(3):276-278  

Selected legal aspects of compulsory confidentiality

Lukáš Prudil

Vnitr Lek 2015, 61(3):264-267