Vnitr Lek 2015, 61(3):260-263

Hypersensitive reaction after application of heparin with activation heparin induced trombocytopenia in initiation of intermittent haemodialysis

Jan Masopust*, Jiří Charvát, Dana Mokrá, Ondřej Hloch, Jan Háša
Interní klinika 2. LF UK a FN Motol Praha, přednosta prof. MUDr. Milan Kvapil, CSc., MBA

Our report describes the case of patient with hypersensitive reaction regularly arising early after initiation of haemodialysis. This characteristic reaction with pletoric face coloration, bronchospasm, increase of blood pressure, anxiety and decrease of blood oxygen saturation at the consequence and central cyanosis was regularly present without dependence on type of dialysis membrane, drug premedication or prophylactic flushing haemodialysis system by isotonic natrium chloride solution. Low platelet value and trouble-free haemodialysis realized without heparin showed real cause of patients problem. Resolution of this state was regional citrate anticoagulation during intermitent haemodialysis.

Keywords: haemodialysis; heparin induced trombocytopenia; hypersensitive reaction; regional anticoagulation

Received: August 20, 2014; Accepted: January 30, 2015; Published: March 1, 2015  Show citation

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Masopust J, Charvát J, Mokrá D, Hloch O, Háša J. Hypersensitive reaction after application of heparin with activation heparin induced trombocytopenia in initiation of intermittent haemodialysis. Vnitr Lek. 2015;61(3):260-263.
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