Vnitr Lek 2015, 61(3):219-227

Non-celiac gluten sensitivity

Iva Hoffmanová^1,*, Daniel Sánchez²

¹ II. interní klinika 3. LF UK a FN Královské Vinohrady Praha, přednosta prof. MUDr. Michal Anděl, CSc.

² Laboratoř buněčné a molekulární imunologie Mikrobiologického ústavu AV ČR, v.v.i., Praha, ředitel RNDr. Martin Bilej, CSc.

Non-celiac gluten sensitivity has recently been recognized by the scientific community as a part of gluten-related disorders, and is defined as a condition with gastrointestinal and/or extra-intestinal symptoms triggered by gluten ingestion in the absence of celiac disease and wheat allergy. Currently, there is no specific serological marker and non-celiac gluten sensitivity remains a diagnosis of exclusion: testing for celiac disease and wheat allergy must be negative, symptoms must improve with a gluten-free diet, and diagnosis must be confirmed by the gluten challenge. In this article, we discuss current knowledge of pathophysiology, clinical and epidemilogical spectrum, diagnosis, and treatment of NCGS.

Keywords: celiac disease; FODMAPs; gluten-free diet; gluten-related disorders; irritable bowel syndrome; non-celiac gluten sensitivity; wheat allergy

Received: December 8, 2014; Accepted: January 19, 2015; Published: March 1, 2015  Show citation