Vnitr Lek 2005, 51(11):1303-1305

A rare complication after aortocoronary bypass: acute cholestatic hepatitis and agranulocytosis induced by ticlopidin and simvastatin in patients allergic to salicilates

J. Málková1,*, I. Hoffmanová2, J. Knot1, J. Votava3
1 III. interní - kardiologická klinika 3. lékařské fakulty UK a FN Královské Vinohrady, Praha, přednosta prof. MUDr. Petr Widimský, DrSc., FESC
2 II. interní klinika 3. lékařské fakulty UK a FN Královské Vinohrady, Praha, přednosta prof. MUDr. Michal Anděl, CSc.
3 Kardiochirurgická klinika 3. lékařské fakulty UK a FN Královské Vinohrady, Praha, přednosta prof. MUDr. Zbyněk Straka, CSc.

Unusual case of acute cholestatic hepatitis and agranulocytosis associated with the use of antiplatelet agent ticlopidine and simvastatine in patient with ASA intolerance after CABG is reported.

Keywords: ticlopidine; simvastatin; aortocoronary; bypass; clopidogrel; agranulocytosis; cholestatic hepatitis

Received: February 11, 2005; Accepted: May 13, 2005; Published: November 1, 2005  Show citation

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Málková J, Hoffmanová I, Knot J, Votava J. A rare complication after aortocoronary bypass: acute cholestatic hepatitis and agranulocytosis induced by ticlopidin and simvastatin in patients allergic to salicilates. Vnitr Lek. 2005;51(11):1303-1305.
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