Vnitr Lek 1994, 40(11):693-697
[The effect of diuretics on the magnitude of the effect of isosorbide dinitrate given as a single dose and after long-term administration. Ergometric study in patients with stable angina pectoris].
- I. interní klinika FNsP Brno-Bohunice.
Klíčová slova: Adult; Aged; Angina Pectoris, drug therapy, ; Blood Pressure, drug effects, ; Drug Synergism; Electrocardiography, drug effects, ; Exercise Test; Heart Rate, drug effects, ; Humans; Hydrochlorothiazide, pharmacology, ; Isosorbide Dinitrate, administration & dosage, ; Male; Middle Aged; Single-Blind Method
The authors assessed in 24 men with stable angina pectoris, using means of ergometry, the antiischaemic and antianginose effects of a combination of the nitrate Iso-Mack retard and the diuretic Moduretic. The effects were compared with the effects of Iso-Mack retard administered alone and with the effects of placebo. The examination was made after a single dose of the drugs and after three-week administration. The authors revealed that a single dose of the diuretic significantly enhanced the effects of nitrate. During long-term administration the diuretic did not prevent a significant diminution of the nitrate effects. Finally the authors discuss possible mechanisms of development of tolerance for nitrates and possibilities how to influence this tolerance by a diuretic.
Keywords: Adult; Aged; Angina Pectoris /drug therapy/; Blood Pressure /drug effects/; Drug Synergism; Electrocardiography /drug effects/; Exercise Test; Heart Rate /drug effects/; Humans; Hydrochlorothiazide /pharmacology/; Isosorbide Dinitrate /administration & dosage/; Male; Middle Aged; Single-Blind Method
Zveřejněno: 1. listopad 1994 Zobrazit citaci
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