Vnitr Lek 1994, 40(11):693-697

[The effect of diuretics on the magnitude of the effect of isosorbide dinitrate given as a single dose and after long-term administration. Ergometric study in patients with stable angina pectoris].

P Rotrekl, J Vlasínová, J Manousek, O Bocek, Y Vlasicová, S Janousek, B Semrád

I. interní klinika FNsP Brno-Bohunice.

The authors assessed in 24 men with stable angina pectoris, using means of ergometry, the antiischaemic and antianginose effects of a combination of the nitrate Iso-Mack retard and the diuretic Moduretic. The effects were compared with the effects of Iso-Mack retard administered alone and with the effects of placebo. The examination was made after a single dose of the drugs and after three-week administration. The authors revealed that a single dose of the diuretic significantly enhanced the effects of nitrate. During long-term administration the diuretic did not prevent a significant diminution of the nitrate effects. Finally the authors discuss possible mechanisms of development of tolerance for nitrates and possibilities how to influence this tolerance by a diuretic.

Keywords: Adult; Aged; Angina Pectoris, drug therapy, ; Blood Pressure, drug effects, ; Drug Synergism; Electrocardiography, drug effects, ; Exercise Test; Heart Rate, drug effects, ; Humans; Hydrochlorothiazide, pharmacology, ; Isosorbide Dinitrate, administration & dosage, ; Male; Middle Aged; Single-Blind Method

Published: November 1, 1994  Show citation