[Are blood lipids a risk factor for drug addicts? A commentary to an article "Serum lipids in drug addicts" by Wilczek, H., Ceska, R., Zlatohlávek, L].

V Soska

Vnitr Lek 2004, 50(8):575-576

[Recurrent varices].

S Kaspar

Vnitr Lek 2004, 50(8):576-578

[Can be incidence of peritonitis associated with peritoneal dialysis further decreased?].

S Opatrná

Vnitr Lek 2004, 50(8):578-581

[Several diagnostic remarks to a casuistry of fibrillar glomerulonephritis--a morphologists' opinion].

E Honsová

Vnitr Lek 2004, 50(8):582-583

[Serum lipids in drug addicts].

H Wilczek, R Ceska, L Zlatohlávek

Vnitr Lek 2004, 50(8):584-586

UNLABELLED: The background and aim is to study profile of serum lipids in drug addicts using heroin.METHODS AND RESULTS: The study involved 107 drug addicts using heroin (83 men and 24 women). Mean age was 29.3 years (variation 20-47 years). Mean time of using heroin was 6.5 years. Serum lipids (total cholesterol, HDL-cholesterol, triacylglycerol) were measured using enzyme methods. LDL-cholesterol and Body Mass Index (BMI) were calculated. All parameters were significantly decreased (mean levels of total cholesterol 4.31, triacylglycerol 1.29, HDL-cholesterol 1.08 and LDL-cholesterol 2.70 mmol/l). Levels of HDL-cholesterol under 1.0 mmol/l were...

[Recurrence of varices in lower extremities].

D Musil, J Herman, M Duda

Vnitr Lek 2004, 50(8):587-590

Authors have done a retrospective analysis of 94 lower extremities in 88 patients examined from 1996 to 2002 for recurrence of varices in lower extremities. The goal was to find out the most frequent causes of recurrence of varices in lower extremities in patients with history of varices surgery referred to venous guidance clinic because of another onset of varices in lower extreminites or clinical signs of chronic venous insufficiency. Reflux was proved in 78 lower extremities from the total number of 94 (83%) in our sample. Isolated reflux was discovered in 59 extremities in saphenofemoral junction (39 extremities), in saphenopopliteal junction (14...

[Use of assessment of aggregation of thrombocytes induced by cationic propyl gallate to estimate recurrence of cardiovascular complications].

D Stejskal, J Prosková, B Lacnák, D Horalík, A Hamplová, I Oral, I Hrabovská, R Ochmanová, S Adamovská, R Juráková, G Ozanová, J Juchelka, O Kulísková, H Pěnkavová

Vnitr Lek 2004, 50(8):591-599

INTRODUCTION: Recently resistance to an acetylsalicylic acid (ASA) administration has been a frequently mentioned problem. However, to identify ASA nonresponsive patients (ASA resistance) is difficult and common examination procedures can contain important preanalytic, analytic and postanalytic mistakes. Recently a possibility to use aggregometry after induction with cationic propyl gallate (CPG) has been discussed in this context; it's a robust, highly sensitive, and specific method for ASA resistance estimates. We asked ourselves following questions during our work:GOAL: a) Experience patients with acute coronary syndrome (ACS) ASA resistance...

[Deferral of coronary intervention based on measurement of myocardial fractional flow reserve].

M Mates, V Hrabos, P Hájek, M Malý, D Horák, J Fiedler, V Durdil, J Vojácek

Vnitr Lek 2004, 50(8):600-605

BACKGROUND: Myocardial fractional flow reserve (FFR) is a useful method in assessment of functional significance of coronary stenosis. Deferral of intervention of angiographically intermediate lesion based on FFR measurement is safe in selected patient population as previously described. The aim of the study was to assess mid-term results after deferring coronary intervention of intermediate lesion in a non-selected patient population with no respect to the extent of coronary artery disease and to the results of stress tests if performed.METHODS: A coronary intervention of angiographically intermediate lesion (40 - 70% according to QCA) was deferred...

[Families at risk of colon cancer II. Hereditary nonpolyposis colorectal carcinoma].

T Hlavatý, L' Lukác, I Duris

Vnitr Lek 2004, 50(8):606-614

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant inherited disease characterised by almost inevitable development of colorectal carcinoma and/or endometrium and other defined malignancies in affected individuals. HNPCC is caused by a germline mutation in a mismatch repair genes (MMR). The purpose of this review is to summarize current knowledge regarding HNPCC with the focus on recent data on genetic testing, surveillance guidelines and therapy. Available medical databases were searched from 1998 to May 2003 using the keywords "hereditary nonpolyposis colorectal cancer", followed by further search for particular issues. Additional...

[Hypothyroidism and heart failure].

M Rýzlová, F Málek, P Gregor

Vnitr Lek 2004, 50(8):615-618

Effects of thyroid gland hormones on cardiovascular system have been known for many years. Thyroid gland hormones deficiency is connected with a range of metabolic and hemodynamic changes which can contribute to a genesis of heart failure. Recent works refer to an importance of connection of thyroid gland hormones metabolism with heart insufficiency pathophysiology. That is especially a syndrome of a low trijodthyronin level marked as euthyroid sick syndrome which is significantly more frequent in patients with chronic heart failure compared to a population of healthy individuals. Recent clinical works proved that treatment administration of thyroid...

[The latest trends in the treatment peritonitis of the patients on peritoneal dialysis].

B Hájková, P Fixa

Vnitr Lek 2004, 50(8):619-623

Peritonitis is still one of the major complications ambulatory peritoneal dialysis (CAPD). The initial empiric therapy for peritonitis should be effective against most grampositive organisms as well as gramnegative organisms. Intraperitoneal administration antibiotics has the advantage of a high concentration of the antibiotics at the site of infection. The treatment should provide broad coverage of all organisms, without side-effects or risk for the patient and should not provoke the emergence of resistant germs. The present guidelines of the ad hoc advisory committee are of great value in this regard. The ISPD guidelines for treatment of peritonitis...

[Fibrillary glomerulonephritis--a rare cause of nephrotic syndrome].

P Strebl, M Tichý, K Krejcí, S Al Jabry, V Horcicka, K Husek, Z Vernerová, J Zadrazil

Vnitr Lek 2004, 50(8):624-627

Fibrillary glomerulonephritis (FGN) is a rarely diagnosed disease with clinical manifestations such as proteinuria, microscopic hematuria, nephrotic syndrome or decreased kidney function. Around one half of patients develop chronic renal failure in the course of several years. The diagnosis of fibrillary glomerulonephritis is to be established only basing on the results of renal biopsy. Pathognomonic is the electron-microscopic examination, evidencing fibrillar deposits in mesangium and in basal membranes of glomeruli. Fibrils are similar to those seen at amyloidosis, however, with larger diameter, non-linear deposition and do not stain with Congo...

[Case description of the abnormally big pseudoaneurysm in a patient after myocardial infarction].

M Krupauerová, S Sindelárová, A Mokrácek, M Vambera

Vnitr Lek 2004, 50(8):628-632

Authors present a case of a 72 years old woman with an abnormally big left ventricular pseudoaneurysm as a consequence of a rupture of the left ventricular wall during myocardial infarction. Pseudoaneurysm threatens its carrier with both sudden death as a result of the rupture and a progressing heart failure. The patient mentioned has undergone an infero-lateral myocardial infarction complicated with beginning cardiogenic shock in July 2001. Based on coronarography examination which proved only peripheral stenoses in coronary bed a conservative procedure was indicated. In June 2002 the patient was admitted to a hospital for progressive dyspnoea, nonspecific...

[Czech internists--writers].

S Kás

Vnitr Lek 2004, 50(8):633-639

[Ezetimib--a new possibility for combined therapy in hypercholesterolemia].

Milan Kvapil

Vnitr Lek 2004, 50(8):643-644