[Comments on the article "Comparison of the cost effectiveness of treatment of acute myocardial infarct with primary angioplasty and thrombolysis" by Golán et al].

J Vlcek

Vnitr Lek 2003, 49(2):87-88

[The search for the best reperfusion therapy in the treatment of acute myocardial infarct. An editorial on the article by Golán L. et al: "Comparison of cost effectiveness of treatment of acute myocardial infarct with primary angioplasty and thrombolysis"].

S Janousek

Vnitr Lek 2003, 49(2):88-90

[Role of Chlamydia in atherosclerosis].

L Pospísil

Vnitr Lek 2003, 49(2):91

[Diagnostic markers of alcohol abuse].

T Zima

Vnitr Lek 2003, 49(2):92

[Comments on the article by Dastych M. et al: "Diagnostic value of carbohydrate-deficient transferrin, gamma-glutamyltransferase and mean erythrocyte volume as laboratory markers of chronic alcohol abuse"].

H Fingerová

Vnitr Lek 2003, 49(2):92-94

[B-type natriuretic peptide in the differential diagnosis of dyspnea: a useful aid or meaningless ornament? (see the article by Stejskal D. et al: "Personal experience with determination of NT-proBNP in clinical practice" in this issue of Vnitrní Lékarství].

F Kölbel

Vnitr Lek 2003, 49(2):94-96

[Comparison of the cost effectiveness of treatment of acute myocardial infarct with primary angioplasty and thrombolysis ].

L Golán, S Simek, A Linhart, T Cahlík, T Palecek, J C Lubanda, J Korínek, S Beran, M Aschermann

Vnitr Lek 2003, 49(2):97-102

INTRODUCTION: Primary angioplasty (PTCA) or intravenous thrombolysis are the recommended treatment of acute myocardial infarction. According to results of clinical investigations however primary PTCA provides a more favourable short-term as well as long-term prognosis. As this method is much more expensive we were interested in its cost-effectiveness as compared with cheaper intravenous thrombolysis.METHODS: We constructed an decision analysis model (programme DATA 3.5, TreeAge Software) to compare the strategy of primary PTCA and intravenous thrombolysis in acute myocardial infarction. Probabilities of clinical outcomes were obtained from a long-term...

[Comparison of the occurrence of positive and negative vascular remodeling in patients with stable vs unstable angina pectoris].

T Kovárník, V Reznícek, K Novácková, A Linhart, J Bělohlávek, F Holm, J Horák, M Aschermann

Vnitr Lek 2003, 49(2):103-108

BACKGROUND: The vascular remodelling refers to the increase or decrease in EEM (external elastica membrane) area that occurs during development of atherosclerosis. The positive remodeling, which was thought only as a compensatory factor during atheroma development, was also found as a one of the main features of unstable plaque. The intravascular ultrasound is very good tool to measure different type of arterial remodelling. These findings correlate with histologic post-mortem specimen with excellent results.AIM OF THE STUDY: To correlate the remodelling index from patients suffered from stable angina pectoris (SAP) and from patients suffered...

[Effect of chronic Chlamydia infection with non-specific inflammation on cardiovascular complications in acute myocardial infarct].

A J Jaber, J Murín, V Hricák, B Tomasovic, S Kinová, K Kozlíková, W Ghanem, A Radman

Vnitr Lek 2003, 49(2):109-114

It is known that local and systemic inflammatory processes play an important role in the genesis and development of atheroclerotic lesions and in the pathophysiology of acute coronary syndromes. This hypothesis is supported by findings of elevated parameters of the "inflammatory" reaction in the affected blood vessels but also in the blood of atherosclerotic patients. Known risk factors do not explain quite satisfactorily epidemiological cardiovascular phenomena and different manifestations of coronary heart disease. It is very probable that also Chlamydia pneumoniae is a risk factor. This assumption is based on evaluation of seroepidemiological data,...

[Diagnostic value of carbohydrate-deficient transferrin, gamma-glutamyltransferase and mean erythrocyte volume as laboratory markers of chronic alcohol abuse].

M Dastych, J Bednarík, J Pokora, B Friedecký, H Novotná, E Moravcová, J Vávrová

Vnitr Lek 2003, 49(2):115-120

INTRODUCTION: Our research aimed at finding out values of carbohydrate-deficient transferin (CDT), gamma-glutamyltransferase (GGT) and mean corpuscular volume (MCV) for the purposes of future etiological diagnostics of alcohol neuropathy in thin fibres.METHODS: We examined the serum of 80 control subjects (50 women and 30 men), and the serum of 33 alcoholics (20 men and 13 women) with the daily consumption of more than 60 g alcohol in the course of the last four weeks. CDT was determined with the use of microcolumn separation after iron saturation followed by turbidimetric immunoassay (ChronoAlcoI. D., Sangui Biotech, Inc.) on Cobas-Mira analyser....

[Personal experience with determination of NT-proBNP in clinical practice].

D Stejskal, I Oral, B Lacnák, R Juráková, D Horalík, S Adamovská, J Prosková, I Hrabovská, G Ozanová

Vnitr Lek 2003, 49(2):121-126

INTRODUCTION AND OBJECTIVE: Recently in the literature information is found on estimation of natriuretic peptides in the differential diagnosis of dyspnoea. Because in the Czech Republic since the beginning of 2002 routine estimation of NT-proBNP is available (analyzer Elecsys 2010), the objective of our work was to find out whether it is possible to use in the everyday practice of a district hospital estimation of NT-proBNP to differentiate dyspnoea with affection of the heart muscle from other types of dyspnoea.METHOD: A group of 33 patients from the medical department of the Sternberk hospital was examined who attended on account of dyspnoea...

[Contrast nephropathy and its prevention].

R Skulec, J Bělohlávek, T Kovárník, A Linhart, M Aschermann

Vnitr Lek 2003, 49(2):127-133

Contrast-induced nephropathy is one of the adverse events of diagnostic and therapeutic intravascular application of contrast agent. In general, the condition was defined as an increase in the serum creatinine concentration of more than 44 mmol/l or of more than 25% within 48 hours after the contrast agent administration. Other cause of creatinine increase should be excluded. Contrast-induced nephropathy has been reported to be the third leading cause of acute nephropathy in hospitalized patients, occurring at a rate of 1-6% in unselected population and of 30-50% in high-risk patients. One year mortality can be as high as 45% in high-risk patient population....

[Acute adverse effects of dialysis].

K Opatrný

Vnitr Lek 2003, 49(2):134-142

Adverse reactions to dialyzers are a not very frequent, but because of the serious, sometimes fatal course, a dreaded complication of haemodialysis treatment. Most important among these reactions are hypersensitive reactions (anaphylactoid, reaction type A to dialyzer), which develop as a rule within the 10th minute of the procedure, and the reaction caused by the action of perfluorohydrocarbon which develop hours after onset or even completion of haemodialysis. Explanation of the development of hypersensitive reactions (HSR) by complement activation and formation of anaphylatoxins C3a and C5a during contact of blood with the bioincompatible dialysis...

[Long-term effect of catheter ablation of ventricular tachycardia in adult patients with previous surgery of congenital heart defects. 2 case reports].

M Fiala, P Heinc, J Lukl

Vnitr Lek 2003, 49(2):143-147

Two case reports of catheter ablation of sustained monomorphic ventricular tachycardia in two adult patients after previous surgical correction of congenital heart disease are reported. In both patients catheter ablation led to long-term elimination of ventricular tachycardia during follow-up period of 38 and 20 months.

[Teaching of pathologic physiology in the spirit of Dr. Frantisek Póra].

O Rácz

Vnitr Lek 2003, 49(2):148-150