[IgA nephropathy, isolated hematuria and renal biopsy].

J Erben

Vnitr Lek 2003, 49(11):837

[What are indications for surgery in patients with chronic mitral insufficiency?].

V Rozsíval

Vnitr Lek 2003, 49(11):838-839

[Chronic mitral regurgitation].

R Cerbák

Vnitr Lek 2003, 49(11):839-842

[Streptokinase--yes or no--a black and white view].

K Dvorák

Vnitr Lek 2003, 49(11):842-844

[Factor V Leiden and the Slovak population].

J Hudecek, M Dobrotová, J Hybenová, J Ivanková, V Melus, R Pullmann, P Kubisz

Vnitr Lek 2003, 49(11):845-850

The resistance to activated protein C (APC-resistance) based on the presence of factor V Leiden (F V Leiden) is the most frequent thrombophilic condition in the white race population. It contributes to the origin of thrombosis especially in the venous part of blood vessels. Significant geographic differences have been detected within Europe. The aim of this retrospective study was to determine the frequency in the occurrence of F V Leiden: 1. in healthy (asymptomatic) Slovak population, 2. in their consanguineously unrelated members with thrombosis and 3. in patients with myocardial infarction (IM) without or with other known risk factors of this disease...

[Comprehensive care of drug addiction during a 5-year period at the methadone center in Prague].

P Popov, J Becka, H Wilczek

Vnitr Lek 2003, 49(11):851-858

Methadone maintenance program in General Faculty Hospital in Prague has been in operation for five years since August 1997. During this period a broad spectrum of complex care was supported to opioid drug addicts. Not only substitution of methadone or buprenorphine but also psychiatric, social and health care was guaranteed. The goal of this article is the information about our experience achieved during the five-year existence of the methadone maintenance program.

[Desirable and undesirable effects of thalidomide in patients with multiple myeloma].

D Foldyna, J Kamelander, M Krejcí, R Hájek

Vnitr Lek 2003, 49(11):859-868

Thalidomide, an antiemetic administered in 60th of the 20th century to pregnant women, has become notorious for a range of adverse effects which led to its taking off market. In recent years, its antimyeloma effect was discovered. The aim of the work was to evaluate the incidence of adverse reactions to thalidomide. Its therapeutic effect has not been assessed because of a short period of monitoring and diversity of a sample. The assessed sample consisted of 17 patients with diagnosis of multiple myeloma (10 men and 7 women). An average age of patients was 62.9 +/- 9.4. An average time elapsed from making the diagnosis to starting the treatment with...

[IgA nephropathy. Use of modern laboratory methods and renal biopsy for diagnosis].

K Matousovic, V Martínek

Vnitr Lek 2003, 49(11):869-873

IgA nephropathy is the most frequent primary glomerulonephritis worldwide. At its onset, the most common laboratory sign is isolated haematuria often accompanied with mild proteinuria (up to 1.5 g/24 h). The disease displays a progressive course with end-stage renal disease occurring in up to half of patients 20 years after onset. Diagnosis is established by immunofluorescent microscopy of a renal biopsy specimen. Discoveries in the past decade on the pathogenesis of IgA nephropathy together with complex evaluation of its clinical presentation enable to establish diagnosis with a satisfactory degree of probability even without biopsy. IgA nephropathy...

[What are indications for surgery in patients with chronic mitral regurgitation?].

M Vambera, M Setina

Vnitr Lek 2003, 49(11):874-879

This review has been aimed at the presentation of present etiological spectrum of mitral regurgitation and its natural course. A basal survey of pathophysiology of this complicated and insidious defect, which should help to understand its clinical and hemodynamic classification, is presented. The developmental phases, characterized by very long asymptomatic period, when the heart function is compensated and the prognosis is good, are outlined. However, as a paradox of this defect, the contractile function of the left ventricle is damaged as early as in the compensation phase in spite of normal value of the ejection fraction. In the advanced phase the...

[Does streptokinase still have a role in the treatment of acute myocardial infarct?].

S Janousek

Vnitr Lek 2003, 49(11):880-884

Streptokinase was discovered in 1933. Its importance has gradually grown since 1950's of the last century when it was used as the utterly first thrombolytic agent. Since the discovery that majority of acute myocardial infarctions is caused by thrombus in the area of ruptured endothel above the atherosclerotic platelet, it has become the first remedy able of real causal treatment of acute myocardial infarction (AMI). These days it becomes an obsolete remedy because of a range of disadvantages. Neutralizing antibodies for instance remain in organism for many years after its administration, which results in an inefficacious treatment. Moreover it causes...