[Renal excretion of amino acids in patients on a regular dialysis program].

H Nádvorníková, O Schück, V Teplan, J Kaslíková, D Tomková, V Reitschlägerová

Vnitr Lek 1994, 40(4):211-214

In 10 patients with chronic renal failure and a polyfructosan S clearance (CPFS): 1.91-12.70 ml/min (mean 5.68 ml/min) with a preserved residual diuresis (more than 1000 ml/24 hours) renal excretion of 22 amino acids by residual nephrons was investigated before and 12 hours after haemodialysis. It was revealed that 12 hours after haemodialysis a significant drop of the filtered amount of all investigated amino acids occurred. Renal clearance of Ser, Pro, Glu, Gly, Ala, Tyr, Met, Leu and Cit after haemodialysis declined significantly (p < 0.05-0.001). Haemodialysis was not associated with significant changes of fractionated excretions (FE) of amino...

[Protective effect of carvedilol on renal circulation and tissue injury in reperfusion of ischemic kidneys in rats].

L Vacek, K Husek

Vnitr Lek 1994, 40(4):215-218

In one-kidney rats the resting blood flow in the renal artery was recorded for 10 minutes then the artery was clipped for one hour and the following reperfusion blood flow was registered again for 10 minutes. The animals were divided into three groups: Series A, untreated control animals. Series B, two weeks before renal ischemia the rats were fed a diet containing 0.1% of BM-14.190, a derivate of carvedilol. Series C the rats received a diet with 0.1% of carvedilol. The resting renal blood flow was 4.58 +/- 0.13 ml/min (x +/- S.E.M.) in series A whereas 6.36 +/- 0.41 ml/min. in series B and 5.87 +/- 0.59 ml/min. in series C (p < 0.01), also the...

[Success of pharmacologic cardioversion and electric cardioversion in patients with atrial fibrillation or flutter in a 5-year retrospective study].

V Bugán, B Renker, P Brunclík, D Baraniková, E Augustín

Vnitr Lek 1994, 40(4):219-222

The authors evaluated in a five-year retrospective study the success of pharmacological and electric cardioversion in general in 353 patients with atrial fibrillation and in 117 patients with atrial flutter. The success of electric cardioversion in the group with fibrillation arrhythmia was 72%, in the group with atrial flutter 92%. The success of pharmacological cardioversion in the group with fibrillation arrhythmia was 96.2%, in the group with atrial flutter 79.8%. In pharmacological cardioversion in both groups the combination quinidine-isoptin was best.

[Dominant beta-thalassemia alleles in the Czech and Slovak population (beta-thalassemia mutations in 112(T-A) and 121(G-T) codons and the unstable Hradec Králové hemoglobin or alpha 2 beta 2 115 (G17) Ala-Asp)].

K Indrák, V Divoký, V Brabec, L Chrobák, K Mociková, A Sakalová, M Svobodová, J Indráková, T Hammerová, M Zarnovicanová

Vnitr Lek 1994, 40(4):223-230

In four unrelated families of Czech and Slovak origin two nonsense dominant beta-thalassaemic alleles (CD 121 (G-T); CD 112 (T-A)) and in one family simple substitution in codon 115 (GCC-GAC) or alpha 2 beta 2 115 (G17) Ala-Asp HB-Hradec Králové were identified. Mutations in codons 112 and 115 were described for the first time. Phenotypic manifestation of beta-thal. intermedia was revealed in three families with CD 121 (G-T) and in a family with a mutation in CD 112, but the phenotypic manifestations differed markedly in individual subjects. Heinz bodies were detected in erythrocytes of the peripheral blood in two families. An exact explanation of...

[Extrapulmonary tuberculosis with involvement of the reticuloendothelial system and secondary lupus vulgaris].

J Procházka, A Jirásek, J Homolka, V Růzek, B Skálová, J Schwarz

Vnitr Lek 1994, 40(4):231-236

The authors describe a case of extrapulmonary tuberculosis with affection of the reticuloendothelial system in a 59-year-old female patient. After successful treatment the findings in the spleen, bone marrow and the laboratory results had normal levels. The authors draw attention to the diagnostic difficulties. They were able to confirm the diagnosis only by histological examination of biopsy from the pelvic bone. An interesting finding was eruption of lupus vulgaris on the legs in the course of treatment. The authors discuss some aspects of the disease and its differential diagnosis.

[Mechanical lithotripsy of a gastric bezoar].

R Keil, I Námesný, J Zelenková, V Růzek, I Neuman

Vnitr Lek 1994, 40(4):237-239

At the First Medical Clinic of the Faculty Hospital Prague Motol the authors detected during a routine gastroscopic examination of a 71-year-old female patient the presence of a gastric bezoar. The examination was indicated on account of dyspeptic complaints. With regard to the size of the bezoar (50 x 20 mm) the authors decided for mechanical lithotripsy. It proved possible to reduce the concrement during the first session and during subsequent sessions it was broken down to small size and the fragments were eliminated per vias naturales. Several fragments were extracted. Chemical analysis provided evidence of the origin of the concrement in the biliary...

[The patient after myocardial infarct--what next? Diagnostic and examination methods].

J Spinar, J Vítovec, O Hlinomaz

Vnitr Lek 1994, 40(4):240-245

The authors present a review of possible examination methods for the assessment of post-infarction ischaemia and estimation of the prognosis in patients after myocardial infarction. Criteria of the positivity of tests are given, as well as their sensitivity and specificity. The tests are listed according to their availability in different departments and with regard economic aspects, i.e. from the cheapest to the most expensive ones. The outcome of this examination pattern should be indication of coronarography which is the only examination to provide accurate information on the blood supply of the heart muscle and the results of coronarography are...

[Irritable bowel syndrome].

J Kocián

Vnitr Lek 1994, 40(4):246-249

Irritable bowel is a functional gastrointestinal disorder with chronic or relapsing symptoms of abdominal pain and impaired frequency and consistency of the faeces caused by obscure structural or biochemical deviations. The frequency of the condition in civilized countries is estimated to amount to 15-20% of the population and it accounts for 25-50% of all patients in gastroenterological ambulatory departments. From the clinical aspect the type with dominant diarrhoea, typically in the morning and very compelling, and the type with pain and constipation are known but even combinations of the two types are encountered. A psychosomatic disorder of the...

[Changes in lipoprotein metabolism in patients with diabetes mellitus and the effect on lipid profile in diabetics].

T Mudríková, I Tkác, M Takác

Vnitr Lek 1994, 40(4):250-254

Diabetic patients have a 2 to 4 times higher risk of development of atherosclerosis than non-diabetic subjects. One of the risk factors of atherosclerosis is an impaired lipid and lipoprotein metabolism which is influenced by the type of diabetes, the degree of its metabolic compensation, character of treatment and other concurrently present metabolic abnormalities. In metabolically balanced type 1 diabetes the levels of commonly assessed lipoproteins do not differ from those in non-diabetic subjects, the HDL-cholesterol level can be even higher. The lipid profile of type 2 diabetics is not very homogeneous, however, usually elevated levels of VLDL-triglycerides...

[Interferon alfa in the treatment of malignant lymphomas].

Z Adam

Vnitr Lek 1994, 40(4):255-258

In follicular lymphomas with a low malignancy combined treatment (interferon alpha and chemotherapy) achieves the same number of remissions as chemotherapy alone, remissions after combined treatment are longer. Maintenance treatment with interferon alpha prolongs the remissions period. Maintenance treatment with interferon alpha can be recommended as standard treatment. For combined initial treatment it is important to define the optimal time schedule and dosage of interferon. Interferon alpha holds its place in the treatment of skin lymphomas where it leads in a great proportion of lymphomas to remission, and in angioimmunoblastic lymphadenopathy....

[Chromium--a biologic element. What do we know about it?].

O Macharácek

Vnitr Lek 1994, 40(4):259-261