[Concept of metabolic deviations].

A J Charvát

Vnitr Lek 1975, 21(1):1-5

Disturbance of metabolism has to do always with systems. A change in one unit results in a flow of matter, energy or information to other units. The whole or almost the whole system participates at this chain reaction. Never a simple newtonian reaction can be encountered at this occasion, with its direct cause-effect connection. At least always the feed-back mechanism is triggered. Generally, however, multiple loops of the feed-back mechanism are activated. No strict determinism is present here. In the nature common laws for living and lifeless objects are valid. It does not matter that we cannot yet define the life in terms of classical physics. It...

[Changes in the composition of liver tissue and blood in liver steatosis].

E Brixová, V Dzúriková, P Kolesár, P Weisz

Vnitr Lek 1975, 21(1):6-13

The results of clinical and biochemical evaluation of liver steatosis are presented. The advantage of the quantitative determination of lipids in the liver tissue is underlined. A direct correlation between accumulation of fat in the liver and that of lipid phosphorus in blood was found. The concept is put forward that in the group of patients studied the increased supply of lipids to the liver prevails in the mechanism of development of steatosis.

[Anemia in old people].

D Dieska, K Gocárová

Vnitr Lek 1975, 21(1):14-21

In older age the incidence of anemia is more frequent, in patients over 15 years of age anemia was found in 16%, whereas in patients over 60 years of age in 22.5%. The study was done on hospitalized patients. In younger age groups anemic women were more numerous, in older patients on the contrary the majority of anemic patients were men. In both age groups anemia is mostly of a lighter form, but in the older age group a serous form of anemia is more frequent. The development of anemia is due in the first place to economic and social conditions, insufficient health and social care of old persons. The leading cause of anemia is malnutrition of the old,...

[Glycide metabolism disorder in renal failure, therapeutic sequelae].

R Dzúrik, P Cernácek

Vnitr Lek 1975, 21(1):22-27

The in vitro effects of increased concentration of urea, creatinine, phosphate, glucose and of decreased concentration of potassium and calcium on the inhibitory effects of IGU was studied. The following results were obtained: 1. Urea, creatinine and increased concentration of phosphate in the degrees significant clinically did not influence the effect of IGU. 2. Decreased concentration of potassium did not influence utilization of glucose, but abolished completely the inhibitory effect of IGU. 3. Increased concentration of glucose increased its utilization, but did not abolish the inhibitory effect of IGU. The therapeutic implications of these findings...

[Problems of myocardiopathies in the clinical and experimental cardiology].

J Gvozdják, A Gvozdjáková, V Bada, F Krutý

Vnitr Lek 1975, 21(1):28-34

The first part of the study deals with the early diagnosis of cardiomyopathies on the ground of physical examination of the patients and of his ECG and X-ray finding. It is stressed, that in the majority of cases already this set of examination can in the physicial of the first contact awake a suspicion of cardiomyopathy. Further precision of diagnosis demands examination in a cardiological center where the facilities for cardiac catheterization, angiography and coronarogrpahy are available. The second part of the study deals with the problem of mechanism of the early heart failure in caridomyopathies. Studying the structural, metabolic and functional...

[Did the introduction of rehabilitation improve the course and prognosis of myocardial infarct?].

V Haviar, J Postulka, J Kasper, V Lániková, K Ziska

Vnitr Lek 1975, 21(1):35-39

Experience with early mobilization and rehabilitation of patients after myocardial infarction in a coronary care unit is presented. There was not visible unfavorable influence of the early rehabilitation in patients after overcoming the acute phase of myocardial infarction. Early rehabilitation had a positive influence on physical as well as on mental condition of patients and resulted in a shortened stay in hospital and duration of impaired working capacity.

[Experiences in the determination of hepatitis B antigen in acute viral hepatitis].

V Houbal, P Jezek, J Horecká

Vnitr Lek 1975, 21(1):40-44

The antigen of hepatitis B was repeatedly examined in 1356 adults patients with acute viral hepatitis. In 701 patients the HBAg was positive at the beginning of illness and in 657 was negative. The maximum of the negative HBAg results could be found in the lower age groups, whereas the maximum of the positive HBAg results was shifted to the 5th and 6th decade. In HBAg positive cases of hepatitis more numerous anicteric and asymptomatic forms could be observed on the other hand, however, at the same time also o more cholestatic forms and subacute necrotizing and malignant forms appeared. The HBAg positive hepatitis had on average also a more serious...

[Effect of ethanol on blood serotonin level].

J Kollár, A Kohút

Vnitr Lek 1975, 21(1):45-48

The level of blood serotonin was determined in 11 healthy young men after administration of 1.0 g ethanol per 1 kg of body weight and in healthy dogs after administration of 2.0 g of ethanol per 1 kg of body weight. In men there was no substantial change in the blood level of serotonin. After administration of 2.0 g of ethanol per 1 kg of body weight in dogs, the blood level of serotonin was not found changed in the 60th minute of the experiment. After 4 hours after administration of ethanol already a significant decrease of the serotonin level appeared. After 24 hours following administration of ethanol there was a slight increase of the serotonin...

[Effect of ethanol and inderal on the heart cycle].

J Kollár, J Lukáci, M Takác

Vnitr Lek 1975, 21(1):49-57

Ingested ethanol at a dose of 1.0 g per 1 kg of body weight in an experiment on healthy young men changes in the 30th minute the duration of individual phases of the heart cycle. By the effct of ethanol in the dose mentioned and by administration of 20 mg of Inderal, the negative inotropic effect in the 60th minute and by increased index of preejection period as well as by decreased volues of the index of tension of the left ventricular heart muscle. Left ventricular ejection period is only slightly shortened by the influence of both ingested substances. Ethanol as well as Inderal prolong the interval of isovolumic relaxation, but at the some time...

[Acute toxic liver lesion through industrial noxious substances and drugs in higher than therapeutic doses].

J Filipová, J Filip

Vnitr Lek 1975, 21(1):58-62

From the accessible material an attempt was made to estimate the frequency of acute toxic disturbances of liver and its relation to all intoxications together with special regard to the composition of noxious substances on the conditions of this country. From 3700 cases of all acute intoxications or serious attempts of intoxication 54 cases were discovered to have marked hepatic disturbance (about 1.5%). The noxious substance causing hepatic disturbance in the overwhelming majority of cases was tetrachlormethan (and chemically related substances) or new herbicide drugs of the dipyridine compounds. The last mentioned group is highly lethal and the more...

[Usability of methods for the determination of minute cardiac volume under clinical conditions].

M Novák

Vnitr Lek 1975, 21(1):63-74

Methods for determination of cardiac output are described and their evaluation and possibilities to use them in clinical practice mentioned. Out of the invasive methods apart from the classical Fick's method, the dye dilution method is of advantage during catheterization, being relatively simple and ready to be easily repeated if necessary directly at the bed side. The common disadvantage of all invasive methods is the disturbance of the patient's basal state. Noninvasive methods yield results suitable more or less for orientation only. From these techniques the indirect method of Fick using the rebreathing of CO2 is simple and can be applied at the...

[Basis of statistical methodology in medicine. VII. Description of the statistical complex].

J Holcík, A Gerylovová

Vnitr Lek 1975, 21(1):75-81

Description of statistical population is based on clear classification of the data obtained, construction of tables and graphs and calculation of suitable statistical parameters. The proceeding of calculation of the arithmetical means, distribution, standard deviation, and of coëfficient of variance is described.

[60th birthday of Prof. T. R. Niederland, M.D., D.Sc].

E Brixová, R Dzúrik, J Gvozdják

Vnitr Lek 1975, 21(1):83-85

[60th birthday of Prof. Josef Procházka, M.D., C.Sc].

J Cernohorský

Vnitr Lek 1975, 21(1):85-86

[In memory of Assistant Prof. Bedrich Hejda M.D. (May 13, 1901--Dec 13, 1974)].

J Syllaba

Vnitr Lek 1975, 21(1):87-88