Přichází doba bezlepková? - editorial

Michal Šenkyřík, Jitka Prokešová

Vnitr Lek 2019, 65(1):5-6 | DOI: 10.36290/vnl.2019.001  

Kreatin ve vnitřním lékařství a jeho vliv na ledvinné funkce - editorial

Vladimír Teplan

Vnitr Lek 2019, 65(1):7-10 | DOI: 10.36290/vnl.2019.002  

Přímá perorální antikoagulancia u pacientů s nádorovým onemocněním - editorial

Petr Kessler

Vnitr Lek 2019, 65(1):11-12 | DOI: 10.36290/vnl.2019.003  

Prescription and dosage of RAAS inhibitors in patients with chronic heart failure in the FAR NHL registry

Monika Špinarová, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Karel Lábr, Ondřej Ludka, Jiří Jarkovský

Vnitr Lek 2019, 65(1):13-18 | DOI: 10.36290/vnl.2019.004  

Background:Congestive heart failure with reduced ejection fraction is a common clinical condition with a serious prognosis. Treatment focuses on improving the symptoms and preventing the progression of the disease. First-line therapy include angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARBs). Methods:These data come from the FAR NHL registry (FARmacology and NeuroHumoraL activation). This is a multicenter database of patients with stable systolic heart failure (EF < 50 %) collected between November 2014 and November 2015. Results:A population of 1 100 patients was evaluated,...

Non-celiac gluten/wheat sensitivity: still more questions than answers

Iva Hoffmanová

Vnitr Lek 2019, 65(1):19-23 | DOI: 10.36290/vnl.2019.005  

Non-celiac gluten/wheat sensitivity (NCG/WS) is a syndrome characterized by intestinal and extra-intestinal symptoms elicited by gluten/wheat ingestion in the persons, who are not affected by celiac disease and wheat allergy. Due to the lack of established biomarkers, the diagnosis of NCG/WS is based on the clinical picture, and it is necessary to validate it in well-defined double-blind, placebo-controlled challenge (The Salerno Experts' Criteria). In the article is discussed a current knowledge of NCG/WS in terms of pathogenesis, diagnosis and treatment.

Diagnostic pitfalls of celiac disease

Iva Hoffmanová, Daniel Sánchez, Helena Tlaskalová-Hogenová

Vnitr Lek 2019, 65(1):24-29 | DOI: 10.36290/vnl.2019.006  

Celiac disease is a very common autoimmune disorder caused by the ingestion of dietary gluten products in genetically susceptible persons. Its global prevalence is estimated around 1 %. However, the most cases are not diagnosed. Clinical presentation is widely variable with the involvement of various human systems. Besides a clinical picture (that is often non characteristic), the diagnosis is based on positivity of serological testing (tissue transglutaminase autoantibodies) and histological evaluation of small intestinal mucosa. The article presents a rational diagnostic approach to celiac disease.

Potential possibility of phosphocreatine usage in internal medicine

Matej Vnučák, Renáta Michalová jr, Karol Graňák, Jakub Benko, Marián Mokáň

Vnitr Lek 2019, 65(1):30-36 | DOI: 10.36290/vnl.2019.008  

Adenosintriphosphate is basic unit of cellular energetics, although during situations of high energy demand, cell had developed metabolic inert molecules - phosphagens - including phosphocreatine. Nowadays there are not so many recent publications describing positive effect of phosphocreatine supplementation., its potential benefit in supplementation is mainly in cardiology - acute myocardial infarction, acute or chronic heart failure. Another field of medicine with potential use of phosphocreatine is nephrology - in dialysis patients, or in psotemnopausal women in prevention of osteoporosis. In following article, we present review of studies describing...

Systemic inflammatory response with high CRP values as the dominant symptom of multiple myeloma

Zdeněk Král, Zdeněk Adam, František Folber, Mojmír Moulis, Miroslav Tomíška, Lucie Říhová, Martin Štork, Alena Buliková, Luděk Pour, Marta Krejčí, Viera Sandecká, Renata Koukalová, Zdeněk Řehák, Zdenka Čermáková

Vnitr Lek 2019, 65(1):37-44 | DOI: 10.36290/vnl.2019.009  

A man aged 60 years was examined for intense inflammatory response, night sweats, subfebrile and later febrile temperatures and a weight loss of 18 kg in 7 months. CRP was 270 mg/l, i.e. more than 20 times the upper limit of the physiological range. Reactive leukocytosis (10 × 10⁹/l), thrombocytosis (530 × 10⁹/l), increased fibrinogen (greater than 7 g/l), and anemia with hemoglobin of 80 g/l were present. No infection or systemic autoimmune disease has been proven. The patient had normal renal function and had no osteolytic deposits detectable by FDG-PET/CT. The procalcitonin level was not elevated. The bone marrow examination...

Direct oral anticoagulants in oncology in clinical praxis

Juraj Sokol, František Nehaj, Marianna Kubašková, Michal Mokáň, František Kovář, Martin Jozef Péč, Marián Mokáň

Vnitr Lek 2019, 65(1):45-50 | DOI: 10.36290/vnl.2019.010  

Relation between oncological diseases and venous thrombo-embolism (VTE) is well known for almost 2 centuries. In 1823 Bouillaud assumed by three patients with tumor and recent deep vein thrombosis (DVT), that peripheral edema of lower limbs emerges as a result of "obturation" of veins by "fibrinous coagulum" (caillot fibrineux), which was induced by oncological disease. French physician Armand Trousseau wrote about this relation in his book "Phlegmasia alba dolens" again in the year 1865. Many studies were developed in times of Bouillaud a Trousseau, which just confirmed existence of relation between tumor and VTE. Oncological disease presents a significant...

The combination of acromegaly and Klinefelter syndrome in one patient

Ivana Ságová, Dušan Pávai, Daniela Kantárová, Anton Vaňuga, Jurina Sadloňová, Peter Vaňuga, Milan Dragula

Vnitr Lek 2019, 65(1):51-55 | DOI: 10.36290/vnl.2019.011  

Acromegaly is a rare disorder usually caused by a benign tumour of the pituitary gland. Long-term presence of elevated growth hormone (GH) and insulin like growth factor 1 (IGF1) levels accompanying this disease is associated with complications such as cardiomyopathy, diabetes mellitus, sleep apnoea and arthropathy. Incidence of acromegaly is 3-4 patients per million per year. Klinefelter syndrome (KS) is the most common sex chromosome disorder occuring in about 1/500 live male births. Common physical features include particularly small testes, among other symptoms are tall stature, reduced muscle tone, delayed pubertal development, lack of secondary...

Interní hematologická a onkologická klinika LF a FN Brno slaví 30 let: vzpomínky na jejího zakladatele prof. Jiřího Vorlíčka

Zdeněk Adam, Zdeněk Král

Vnitr Lek 2019, 65(1):56-59  

Prof. MUDr. Ivo Dvořák, DrSc. oslavil 90. narozeniny!

Miroslav Souček

Vnitr Lek 2019, 65(1):60  

Vzpomínka na pana profesora Ctirada Johna *15. 8. 1920 †12. 10. 2018

Jindřich Lokaj

Vnitr Lek 2019, 65(1):61-62  

Zemřel MUDr. Pavel Jerie - skvělý lékař, internista a kardiolog

Jiří Vítovec

Vnitr Lek 2019, 65(1):63-64 | DOI: 10.36290/vnl.2019.015  

Zemřela Eva Klima, M.D.

Michael Aschermann

Vnitr Lek 2019, 65(1):64  

Za profesorem MUDr. Jaroslavem Blahošem, DrSc.

Štěpán Svačina

Vnitr Lek 2019, 65(1):65-66  

Errata et corrigenda

Vnitr Lek 2019, 65(1):29