Vnitr Lek 2019, 65(1):24-29 | DOI: 10.36290/vnl.2019.006

Diagnostic pitfalls of celiac disease

Iva Hoffmanová1,*, Daniel Sánchez2, Helena Tlaskalová-Hogenová2
1 II. interní klinika 3. LF UK a FN Královské Vinohrady, Praha
2 Laboratoř buněčné a molekulární imunologie Mikrobiologického ústavu AV ČR, v.v.i., Praha

Celiac disease is a very common autoimmune disorder caused by the ingestion of dietary gluten products in genetically susceptible persons. Its global prevalence is estimated around 1 %. However, the most cases are not diagnosed. Clinical presentation is widely variable with the involvement of various human systems. Besides a clinical picture (that is often non characteristic), the diagnosis is based on positivity of serological testing (tissue transglutaminase autoantibodies) and histological evaluation of small intestinal mucosa. The article presents a rational diagnostic approach to celiac disease.

Keywords: celiac disease; Marsh classification; tissue transglutaminase autoantibodies; villous atrophy

Received: February 1, 2018; Accepted: May 25, 2018; Published: January 1, 2019  Show citation

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Hoffmanová I, Sánchez D, Tlaskalová-Hogenová H. Diagnostic pitfalls of celiac disease. Vnitr Lek. 2019;65(1):24-29. doi: 10.36290/vnl.2019.006.
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