Vnitřní lékařství, 1996 (vol. 42), issue 5
[Comparison of dynamic and isometric loading in echocardiographic examinations in patients with ischemic heart disease].
J Spác, M Blaha, H Nĕmcová, Z Lupínek, I Dvorák
Vnitr Lek 1996, 42(5):303-307
The objective of the work was to compare functional indicators of the left ventricle during isometric (HG) and dynamic (Ergo) echocardiographic load examinations in patients with different grades of ischaemic heart disease. In group A they compared results in 34 patients with affection of three coronary arteries and in group B 15 patients with 1-2 coronary arteries affected. They evaluated the systolic, diastolic blood pressure, heart rate (HR), the index of the diastolic end volume EDV/m2, the index of the systolic end volume ESV/m2, Limacher's index for evaluation of left ventricular motility and the left ventricular ejection fraction (EF) at rest...
[Dobutamine stress echocardiography in patients with acute myocardial infarct].
V Chaloupka, L Elbi, S Janousek, S Nehyba
Vnitr Lek 1996, 42(5):308-313
The objective of the present work was to evaluate dobutamine echocardiography in patients after myocardial infarction. The group of patients comprises 39 subjects, age 54 +/- 10 years with a first non-complicated myocardial infarction treated by thrombolysis. The patients were examined on the 5th-7th day with small amounts of dobutamine (5 and 10 micrograms/kg/min.) and a maximal test after two weeks and three months after the myocardial infarction. During the week after the first maximal test coronarography was made in 33 patients. During the first examination at rest the authors observed asynergy in 237 of 780 segments. Low dobutamine doses revealed...
[Changes in platelet activity in invasive cardiologic procedures].
J Malý, M Pecka, M Pleskot, D Cernohorský, V Pidrman, J Stásek, M Bláha, O Siroký, L Jebavý
Vnitr Lek 1996, 42(5):314-319
The authors revealed some changes in the platelet activity in patients with invasive cardiological procedures. Changes of the platelet function were manifested by an enhanced aggregation of platelets in vivo, an increased secretion from alpha granules and increased release of prostaglandin metabolites from platelets and from the vascular wall. Acetylsalicylic acid (ASA) suppressed the formation of circulating platelet aggregates in vivo, but the platelet activity was manifested by another mechanism, independent on ASA. The authors recorded therefore an increase of prostaglandin metabolites and PF4 even in patients who were treated with ASA before the...
[Free oxygen radicals and rheumatic diseases].
M Kucera, J Racek, V Holecek
Vnitr Lek 1996, 42(5):320-323
The authors assessed in blood some indicators of the reaction of the organism to the formation and action of free radicals in patients with rheumatoid arthritis, with other inflammatory articular diseases selected at random and with degenerative diseases of the joints and spine. From the results ensues that subjects with inflammations of the synovial membrane respond relatively frequently by a rise of indicators of the antioxidant system such as the activity of superoxide dismutase, glutathione peroxidase or the antioxidant capacity of plasma. Obviously a defence reaction of the organism is involved to the increased formation and action of free oxygen...
[Laboratory markers in hepatitis C virus infection in patients with antibody formation disorders treated with immunoglobulin preparations].
J Litzman, J Pejcochová, J Lokaj
Vnitr Lek 1996, 42(5):324-326
The presence of hepatitis C virus (HCV) was investigated in 20 agammaglobulinemic patients using polymerase chain reaction (PCR) and by specific anti-HCV antibodies detection. Fourteen patients suffered from common variable immunodeficiency (CVID), 5 patients from X-linked agammaglobulinemia and one from specific antibody-formation deficiency. All patients were treated by the replacement immunoglobulin therapy (6-30 years), in 19 of them also intravenous immunoglobulin was used. Although 2 patients suffered from chronic hepatic disease (chronic active hepatitis and granulomatous hepatitis of unknown origin), in none of the investigated patients any...
[Interferon alpha in the treatment of chronic myeloid leukemia].
E Tóthová, M Fricová, N Stecová, E Svorcová, M Surová, A Kafková, T Guman, B Mudronová
Vnitr Lek 1996, 42(5):327-330
The authors present their results assembled in patients with chronic myeloid leukaemia (CML) to whom they administered interferon alpha (IFN) in the chronic stage of the disease. They evaluated the survival of patients and the haematological and cytogenetic response. They recorded a favourable haematological response in patients with CML to IFN treatment comparable with data reported in the literature. They assume that the smaller number of cytogenetic responses is due to the smaller percentage of patients in the early chronic stage and short period of hydroxyurea administration at the onset of treatment. They consider interferon alpha, similarly as...
[Occurrence of smoking in a southern Moravian District in comparison with the Prague 8 District].
V Vondra, M Reisová, P Petrík, Z Hlobil, J Kozák
Vnitr Lek 1996, 42(5):331-335
From the literature ensues that in 1995 we cannot expect that in the Czech Republic the ratio of smoking in the mortality from lung cancer, chronic obstructive pulmonary diseases and cardiovascular diseases will decline, as compared with 1990. The prevalence of smoking assessed in an epidemiological study in 1992 in the district of Uherské Hradistĕ was in adults 31% and in ex-smokers 16%. In Prague 8 the prevalence was similar-32% and 17%. Adults aged 21-60 years smoked most frequently (in Uherské Hradistĕ from 21 to 40, in Prague from 41-60 years). Statistically more significant prevalence of smoking was recorded in patients with chronic...
[Diagnosis of chronic massive pulmonary thromboembolism in elderly patients].
S Koval, M Takác, E Szabová, I Drahovská, K Kriegerová, J Vancík, J Klimcík, J Zimácek, J Takács
Vnitr Lek 1996, 42(5):336-341
Chronic massive thromboembolism of the pulmonary artery is an occlusion of the major branches of the pulmonary artery which develops as a result of repeated embolisms, as a result of non-dissolution and organizing of a thrombus or retrograde growth of a thrombus. The authors observed four elderly patients with chronic massive pulmonary embolization. In their clinical picture dominated progressing dyspnoea and signs of right heart failure. In the diagnosis perfusion scan of the lungs and pulmoangiographic examination plays an important part as they revealed even unilateral absence of pulmonary circulation. This examination was stimulated by weaker respiration...
[Fulminant liver failure in poisoning by Lepiota helveolla Bres].
P Studeník, A Průcha, P Krifta, D Zeman
Vnitr Lek 1996, 42(5):342-344
The authors describe an uncommon and severe intoxication with the mushroom Lepiota Helveolla Bres. which manifested itself by fulminant hepatic failure. The possibility of urgent transplantation of the liver was considered. After conservative treatment the patient recovered, however, completely. In the conclusion the authors' view is discussed as regards indications of urgent transplantation of the liver in intoxications with mushrooms which may cause fulminant hepatic failure.
[Treatment of multiple myeloma].
R Hájek, I Vásová, Z Adam, M Krejcí, J Mayer, M Krahulová
Vnitr Lek 1996, 42(5):345-350
A new era of multiple myeloma management includes new approaches such as genetic marking and gene therapy, immunotherapy, stimulation of graft versus myeloma effect, etc. Intensive clinical research is also focused on the detection of minimal residual disease and bone marrow purging. Clinical trials have begun and the first results are promising, though preliminary. The combinations of new types of therapeutical approaches with the most efficient regimens used until now could form a new type of MM management strategy that better involves minimal residual disease.
[Erythropoietin in oncology. II. Evaluation of the effectiveness of erythropoietin in hematologic and oncologic diseases].
Z Adam, M Krejcí, J Vorlícek
Vnitr Lek 1996, 42(5):351-358
Erythropoietin can be successfully used in the treatment of anaemia induced by chemotherapy and radiotherapy as well as for the treatment of anaemia induced by malignant disease without previous chemotherapy of radiotherapy. Erythropoietin administered during chemotherapy is effective in 50-70% patients, it has a more marked effect as a supplement to chemotherapy with cisplatinum and carboplatinum than non-platinum regimens. Erythropoietin reduces the consumption of red cell concentrates during chemotherapy on average by one half. Long-term administration of erythropoietin in anaemia caused by malignant disease alone proves most effective in multiple...
[Autoimmunity and glutamate decarboxylase antibodies in the pathogenesis of type I diabetes mellitus in experimental and clinical practice].
P Kucera, M Anděl, L Treslová
Vnitr Lek 1996, 42(5):359-367
Diabetes mellitus type 1 (DM type 1) is a chronic, organ specific autoimmune disease. Autoantibodies against the islets of Langerhans (ICA) are found in 71%, against insulin (IA) in 65% against glutamate decarboxylase (GAD) in 67-77% of children with DM type 1; in their close relatives and in patients with a more prolonged persistence of DM type 1 these antibodies and manifestations of cell-mediated autoreactivity are found less frequently also as a sign of the autoimmune character of DM type 1. In the pathogenesis of DM type 1 with the help of experimental mammalian models an idea on the genesis of the disease was obtained--activation of autoimmunity...