Vnitr Lek 1996, 42(5):314-319

[Changes in platelet activity in invasive cardiologic procedures].

J Malý, M Pecka, M Pleskot, D Cernohorský, V Pidrman, J Stásek, M Bláha, O Siroký, L Jebavý

2, katedra vnitrních oborů LF UK, Hradec Králové.

The authors revealed some changes in the platelet activity in patients with invasive cardiological procedures. Changes of the platelet function were manifested by an enhanced aggregation of platelets in vivo, an increased secretion from alpha granules and increased release of prostaglandin metabolites from platelets and from the vascular wall. Acetylsalicylic acid (ASA) suppressed the formation of circulating platelet aggregates in vivo, but the platelet activity was manifested by another mechanism, independent on ASA. The authors recorded therefore an increase of prostaglandin metabolites and PF4 even in patients who were treated with ASA before the invasive examination.

Keywords: Angioplasty, Balloon, Coronary; Aspirin /pharmacology/; Cardiac Pacing, Artificial; Coronary Angiography; Female; Humans; Male; Middle Aged; Platelet Activation /drug effects/

Published: May 1, 1996  Show citation