Vnitr Lek 2010, 56(12):1303-1309

Birth weight and genetic risk of type 2 diabetes in Czech population

D. Vejražková*, M. Vaňková, P. Lukášová, J. Včelák, O. Bradnová, S. Pražáková, H. Kvasničková, B. Bendlová
Oddělení molekulární endokrinologie Endokrinologického ústavu Praha, ředitel doc. MUDr. Vojtěch Hainer, CSc.

Introduction:
Birth weight is associated with type 2 diabetes mellitus and other late-onset metabolic diseases. Reduced birth weight is associated with an increased risk of insulin resistance, type 2 diabetes, and atherosclerosis. Also high birth weight represents risk factor for development of type 2 diabetes later in life. In this study, we investigate whether type 2 diabetes risk-confering alleles and biochemical as well as anthropometrical type 2 diabetes risk markers associate with birth weight in our Czech cohort.

Results:
Association between high birth weight and higher BMI in adulthood was found. Low birth weight was associated with higher glycaemia and insulinaemia as well as lower peripheral insulin sensitivity during oGTT. The examination of candidate genes provides evidence that Ngn3 and PPARα are involved in final birth weight regulation.

Conclusion:
According to our results, we suggest that birth weight should be an integral part of medical history record.

Keywords: birth weight; type 2 diabetes mellitus; body composition; insulin sensitivity; type 2 diabetes mellitus candidate genes

Received: October 4, 2010; Published: December 1, 2010  Show citation

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Vejražková D, Vaňková M, Lukášová P, Včelák J, Bradnová O, Pražáková S, et al.. Birth weight and genetic risk of type 2 diabetes in Czech population. Vnitr Lek. 2010;56(12):1303-1309.
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