Vnitr Lek 2025, 71(2):103-106 | DOI: 10.36290/vnl.2025.018

Diabetes mellitus and chronic renal insufficiency

Peter Girman

Centrum diabetologie, IKEM, Praha

With the increasing number of diabetics in the population, there is also a rise in both microvascular and macrovascular complications. Kidney damage represents one of the leading causes of mortality in patients with diabetes. The classification of diabetic nephropathy is based on the glomerular filtration rate and the degree of albuminuria, categorizing patients into risk groups according to their mortality risk. The treatment of these patients is based on data from large multicenter studies, which have demonstrated cardiovascular benefits, particularly with the use of gliflozins. Therefore, gliflozins and statins, together with metformin, are among the first-line treatment options for patients with type 2 diabetes mellitus and renal impairment. Comprehensive care for these patients should also include regular dietary consultations, physical activity, and psychological support. The situation is different for patients with type 1 diabetes mellitus, where the use of gliflozins is not recommended. In this group, the cornerstone of pharmacotherapy remains ACE inhibitors or sartans, along with adequate diabetes management. In advanced stages of the disease, it is crucial to refer patients to specialists in a timely manner for the evaluation of transplantation therapy.

Keywords: diabetes, nephropathy, gliflozins, classification.

Accepted: March 18, 2025; Published: March 27, 2025  Show citation