Vnitr Lek 2024, 70(8):502-506 | DOI: 10.36290/vnl.2024.096

How microorganisms evade the immune system

Karolína Absolonová, Petr Matucha, Ivan Šterzl
Oddělení klinické imunoendokrinologie, Endokrinologický ústav, Praha

Microorganisms have evolved a wide variety of strategies to evade both the innate and adaptive immune systems during evolution, and some of these strategies are addressed in our review. Microorganisms can use the similarity of their proteins to host proteins, produce anti-inflammatory factors, disrupt the complement system, affect the function and block the synthesis of cytokines, inhibit the recognition of immunoglobulins, reduce the expression and modify antigens on their surface, disrupt the processing and presentation of antigen by immune cells, enter immune cells , influence cell apoptosis, modulate immune cell functions or influence hormone production. These escape strategies must be taken into account when treating infectious diseases.

Keywords: escape strategies of microorganisms, innate and adaptive immunity.

Accepted: November 27, 2024; Published: December 18, 2024  Show citation

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Absolonová K, Matucha P, Šterzl I. How microorganisms evade the immune system. Vnitr Lek. 2024;70(8):502-506. doi: 10.36290/vnl.2024.096.
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