Vnitr Lek 2012, 58(6):473-476

Cardiac symptoms in a patient with Addison's disease and hypothyreosis on the basis of autoimmune polyglandular syndrome type II

A. Hachová1,*, L. Brunerová2, P. Gregor1
1 III. interní - kardiologická klinika 3. lékařské fakulty UK a FN Královské Vinohrady Praha, přednosta prof. MUDr. Petr Widimský, DrSc., FESC
2 Mediscan Euromedic, s. r. o., Praha, jednatel společnosti MUDr. David Karásek

In many endocrine diseases we can find a heart disorder. We present a case of a young patient aged 34 years, who was examined for non-specific ST-T abnormalities on ECG and a new-diagnosed left ventricle dysfunction with suspicion to the acute coronary syndroma. However, this diagnosis wasn't verified. Endocrinological examination detected the Addison's disease and a severe hypothyreosis. After the hormonal substitution therapy was given, the patient became asymptomatic and the ECG- and echocardiographic changes disappeared.

Keywords: left ventricle dysfunction; non-specific ST-T changes on ECG; Addison's disease; hypothyreosis; type II. autoimmune polyglandular syndroma

Received: December 8, 2012; Accepted: January 15, 2012; Published: June 1, 2012  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Hachová A, Brunerová L, Gregor P. Cardiac symptoms in a patient with Addison's disease and hypothyreosis on the basis of autoimmune polyglandular syndrome type II. Vnitr Lek. 2012;58(6):473-476.
Download citation

References

  1. Pudil R. Srdce a endokrinní onemocnění. In: Vojáček J, Kettner J et al (eds). Klinická kardiologie. Hradec Králové: Nucleus HK 2009: 772-782.
  2. Zamrazil V. Hypotyreóza. In: Stárka L (ed). Endokrinologie. Praha: Triton 2010: 144-147.
  3. Kršek M. Endokrinologie. In: Češka R et al (eds). Interna. Praha: Triton 2010: 332-350, 367-368.
  4. Vondra K. Autoimunitní polyglandulární syndromy. In: Stárka L (ed). Endokrinologie. Praha: Triton 2010: 30-33.
  5. Vlček P. Tyreopatie v ambulantní praxi. Vnitř Lék 2011; 57: 786-790. Go to PubMed...
  6. Mann D. Cardiovascular Effects of Thyroid Hormones. J Clin Endocrinol Metab 2006; 91: 2126-2132
  7. Biondi B. Cardiovascular effects of mild hypothyroidism. Thyroid 2007; 17: 625-630. Go to original source... Go to PubMed...
  8. Gatnar A, Marek B, Pakuła D et al. Thyroid hormones and the cardiomyocytes. Endokrynol Pol 2006; 57: 144-148. Go to PubMed...
  9. Roberts CG, Ladenson PW. Hypothyroidism. Lancet 2004; 363: 793-803. Go to original source... Go to PubMed...
  10. Munk K, Sørensen SH, Andersen NH et al. Heart failure after aortic valve substitution due to severe hypothyroidism. Int J Cardiol 2008; 127: 164-166. Go to original source... Go to PubMed...
  11. Siegenthaler W. Differential diagnosis in internal medicine: from symptom to diagnosis. New York: Thieme 2007: 853-854. Go to original source...
  12. Derish M, Eckert K, Chin C. Reversible cardio-myopathy in a child with Addison's disease. Intensive Care Med 1996; 22: 460-463. Go to original source... Go to PubMed...
  13. Fallo F, Betterle C, Budano S et al. Regression of cardiac abnormalities after replacement therapy in Addison's disease. Eur J Endocrinol 1999; 140: 425-428. Go to original source... Go to PubMed...




Vnitřní lékařství

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.