[Big endothelin and chronic heart failure].

J Spinar, L Spinarová, J Vítovec, O Ludka, G Hubená, M Tomandlová, J Tomandl: II. interní klinika FN u sv. Anny, Brno.

Klíčová slova: Biomarkers, blood, ; Endothelin-1, blood, ; Endothelins, blood, ; Female; Heart Failure, blood, ; Humans; Male; Middle Aged; Protein Precursors, blood, ; Pulmonary Edema, blood, ; Sensitivity and Specificity

In a group of 124 patients the authors investigated the importance of assessment of plasma levels of big endothelin and endothelin 1 in patients with chronic heart failure as compared with other currently used non-invasive parameters. A six fold increase of plasma levels of both substances was found in patients in functional class NYHA IV as compared with patients in class NYHA II-III. But even patients in the milder stage of NYHA had twice as high values as compared with the standard of the healthy population. Similarly patients with interstitial pulmonary oedema had a twice as high level of both parameters as compared with patients who had a normal finding on X-ray or merely a redistribution of the pulmonary vascularization. The sensitivity of assessment of plasma levels is such that this examination could become part of the basic diagnosis.