Vnitr Lek 2001, 47(10):678-681
[Prevalence of viral hepatitis G infection in hemodialysis patients and coinfection with viral hepatitis B and C].
- UK Praha, Farmaceutická fakulta, Hradec Králové.
Klíčová slova: Flaviviridae Infections /complications/; GB virus C /isolation & purification/; Hepatitis B /complications/; Hepatitis C /complications/; Hepatitis, Viral, Human /epidemiology/; Humans; RNA, Viral /blood/; Renal Dialysis /adverse effects/; Risk Factors; Seroepidemiologic Studies
The group of infectious agents causing viral hepatitis was extended by another virus the detection of which was published in 1995. This virus is described as virus of hepatitis G (HGV) or GBV-C virus and is included among RNA viruses family Flaviviridae. Detection of HGV is based on reverse transcription with subsequent amplification of the viral nucleic acid by means of a polymerase chain reaction. The authors examined sera of 82 chronically haemodialyzed patients incl. 22 (26.8%) HGV RNA positive ones, whereby coinfection with HBV was proved in 3 specimens (13%). In 6 HGV RNA positive samples anti-HCV positivity was found (27%), incl. one sample where HCV RNA positivity was proved (4.5%). Raised transaminase activity was found only in three patients with HGV RNA positivity (13.6%). From the presented results ensues that haemodialyzed patients are a high risk group for HGV infection.
Zveřejněno: 1. říjen 2001 Zobrazit citaci