Vnitr Lek 2001, 47(10):664-669
[Statins in the treatment of patients with arterial occlusive disease of the lower extremities].
- Oddĕlení klinické farmakologie FN, Plzen.
Klíčová slova: Adult; Aged; Arteriosclerosis Obliterans, complications, ; Blood Pressure; Female; Humans; Hyperlipidemias, blood, ; Hypolipidemic Agents, therapeutic use, ; Intermittent Claudication, etiology, ; Leg, blood supply, ; Lipids, blood, ; Male; Middle Aged; Simvastatin, therapeutic use,
In patients with advanced atherosclerosis manifested by arterial occlusion in the lower extremities without a baseline blood lipid disorder statin treatment caused improvement of the efficiency, i.e. prolongation of the claudication interval, while in a comparable control group without statins the efficiency deteriorated further. In patients with arterial occlusion of the lower extremities with baseline dyslipidaemia statin treatment proved protective, i.e. at least it retarded the patients' complaints. The authors recorded improvement of the prooxidation state which followed after the dynamics of improvement of the impaired blood lipid spectrum. The results admit a possible part played by the pleiotropic effect of statins.
Keywords: Adult; Aged; Arteriosclerosis Obliterans /complications/; Blood Pressure; Female; Humans; Hyperlipidemias /blood/; Hypolipidemic Agents /therapeutic use/; Intermittent Claudication /etiology/; Leg /blood supply/; Lipids /blood/; Male; Middle Aged; Simvastatin /therapeutic use/
Zveřejněno: 1. říjen 2001 Zobrazit citaci