Vnitr Lek 2001, 47(9):621-626
[In vitro testing for drug resistance and drug sensitivity in clinical oncology].
- Univerzitní onkologické centrum, oddĕlení klinické onkologie FN Brno, pracovistĕ Bohunice.
Klíčová slova: Animals; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor /methods/; Humans; Tumor Cells, Cultured /drug effects/
In vitro methods for testing chemosensitivity and chemoresistance can contribute considerably to more individual chemotherapy of a given patient. Different tests which reflect with a different reliability and specificity the probable ineffectiveness of chemotherapy can be divided into several categories: 1. Indirect tests associated with general biological activity of the tumour. 2. Tests based on the specific relationship to a certain cytostatic. 3. Examination of hormonal receptors. 4. Direct tests based on testing of the sensitivity or resistance of a tumour to different cytostatics in primocultures or stabilized cultures. The submitted review presents information on different methods.
Zveřejněno: 1. září 2001 Zobrazit citaci