Vnitr Lek 2001, 47(6):381-386
[Apoptosis, its mechanisms and medical significance. I. Definition of apoptosis and its progression at the cellular level].
- Ustav klinické imunologie a alergologie Lékarské fakulty UK Hradec Králové.
Klíčová slova: Animals; Apoptosis, physiology, ; Caspases, physiology, ; Cell Death, physiology, ; Humans; Mitochondria, physiology, ; Necrosis; Signal Transduction
Apoptosis is a one example of genetically-regulated cell death. It is characterized by the phylogenetically highly conserved activation of specific genes and proteins followed by energy-consuming proteolytic autodestruction. Apoptosis seems to be physiological and highly selective mechanism to eliminate either old or injured cells in organisms. It is in contrary to mitosis. A highly complex combination of various stimuli both extracellular and intracellular origins is required for induction of apoptosis together with preserved oxidative phosphorylation.
Keywords: Animals; Apoptosis /physiology/; Caspases /physiology/; Cell Death /physiology/; Humans; Mitochondria /physiology/; Necrosis; Signal Transduction
Zveřejněno: 1. červen 2001 Zobrazit citaci