Vnitr Lek 2000, 46(10):673-676
[Treatment of erosive gastropathy caused by nonsteroidal anti-inflammatory agents using low doses of antacids].
- Subkatedra reumatológie Slovenskej postgraduálnej akadémie medicíny, Piest'any.
Klíčová slova: Acute Disease; Adult; Aged; Aluminum Hydroxide, administration & dosage, ; Antacids, administration & dosage, ; Anti-Inflammatory Agents, Non-Steroidal, adverse effects, ; Drug Combinations; Female; Humans; Magnesium Hydroxide, administration & dosage, ; Male; Middle Aged; Prospective Studies; Stomach Ulcer, chemically induced,
In an open clinical, endoscopy controlled study involving 31 patients with erosive NSAIDs-induced gastropathy without Helicobacter pylori infection, the effect of low dose of antacids (120 mmol/l) with aluminium oxide and magnesium oxide (Maalox) administered for 4 weeks was followed. The administration of NSAIDs was not interrupted during the time of treatment. Healing rate of the gastric erosions after four weeks reached 65% (20/31) and endoscopic score in the gastric mucosa proved significant improvement (0.97 +/- 0.49 compared to 0.07 +/- 0.25, p < 0.01). Our results suggest efficacy of low dose antacids containing aluminium in the treatment of NSAIDs-induced gastric erosions.
Keywords: Acute Disease; Adult; Aged; Aluminum Hydroxide /administration & dosage/; Antacids /administration & dosage/; Anti-Inflammatory Agents, Non-Steroidal /adverse effects/; Drug Combinations; Female; Humans; Magnesium Hydroxide /administration & dosage/; Male; Middle Aged; Prospective Studies; Stomach Ulcer /chemically induced/
Zveřejněno: 1. říjen 2000 Zobrazit citaci