Vnitr Lek 1998, 44(11):661-664
[Tissue plasminogen activator and diabetes mellitus].
- I. interná klinika MFN, Martin.
Klíčová slova: Diabetes Mellitus, blood, ; Diabetic Angiopathies, blood, ; Endothelium, Vascular, metabolism, ; Humans; Tissue Plasminogen Activator, metabolism,
tPA has been the independent risk factor of the thrombosis associated with atherosclerosis. There are increased tPA levels in type 1 diabetic patients with vascular complications and tPA is endothelial injury marker in this case. In type 2 diabetes mellitus elevated tPA antigen levels in early disease stage are caused by increased production of complexes with inhibitor (PAI-1) and tPA or fibrinolytic activity has been decreased.
Keywords: Diabetes Mellitus /blood/; Diabetic Angiopathies /blood/; Endothelium, Vascular /metabolism/; Humans; Tissue Plasminogen Activator /metabolism/
Zveřejněno: 1. listopad 1998 Zobrazit citaci