Vnitr Lek 1998, 44(7):435-438

[ATP-sensitive potassium channels and substances affecting them].

Y Pospísilová: II. interní klinika Fakultní nemocnice, Brno-Bohunice.

Klíčová slova: Adenosine Triphosphate, metabolism, ; Hypoglycemic Agents, pharmacology, ; Islets of Langerhans, metabolism, ; Potassium Channels, drug effects, ; Sulfonylurea Compounds, pharmacology,

ATP-sensitive potassium channels are the site of action of the sulphonylurea derivatives that are used to treat non-insulin-dependent diabetes mellitus. These ATP-sensitive potassium channels are also found in myocardial cells and in vascular smooth muscle cells. The sulphonylurea derivatives have been reported to cancel the cardioprotective effects by blocking the opening of these channels in myocardium and vascular smooth muscles. A new sulphonylurea derivative, glimepiride, has been shown to be devoid of vascular ATP-sensitive potassium channel binding properties. The so called potassium-channel-openers, on the other hand, are expected to be used in the treatment of hypertension, ischemic heart disease and asthma bronchiale.