Vnitr Lek 1997, 43(9):615-619

[Relation between parathormone and 1,25-dihydroxyvitamin D3 in chronic kidney failure].

I Sotorník: Institut klinické a experimentální medicíny, Praha.

Klíčová slova: Calcitriol, blood, ; Calcium, metabolism, ; Homeostasis; Humans; Hyperparathyroidism, Secondary, etiology, ; Kidney Failure, Chronic, blood, ; Parathyroid Hormone, blood,

The author gives an account of the basic relations of calcium homeostasis ensuing from the action of calcitropic hormones under physiological conditions and during chronic renal failure. The following are evaluated in relation to the pathogenesis of secondary hyperparathyroidism: a decline of glomerular filtration, the relationship of serum calcium levels and PTH secretion along with analyses of so-called S curves, calcitriol deficit and impaired function of the appropriate receptors, phosphate retention, effect of metabolic acidosis, participation of retained aluminium, possible importance of calcitonin and genetic abnormality, corticoid administration and abolition of oestrogen function.