Vnitr Lek 1995, 41(9):624-628
[Factors with insulin-like effects: IGF-I and GLP-1].
In the submitted review the author discusses two substances secreted into the circulation which can similarly as insulin lower the blood sugar level. These substances are IGF-I (insulin-like growth factor I) and GLP (glucagon-like peptide). While in case of the former it is not certain whether it participates in the glucose homeostasis, this is beyond doubt in the latter. IGF-I prepared by the recombinant technique can be used therapeutically in cases of insulin resistance caused by a receptor or postreceptor disorder, because it may act via its own receptor. Side-effects after larger doses are a problem. GLP-1, the use of which would be useful in type 2 diabetics as it stimulates insulin secretion, is not used so far in therapy because hitherto prepared preparations have a very short period of a effectiveness.
Keywords: Blood Glucose, metabolism, ; Glucagon, adverse effects, ; Glucagon-Like Peptide 1; Humans; Insulin Resistance; Insulin-Like Growth Factor I, adverse effects, ; Pancreatic Hormones, physiology, ; Peptide Fragments, adverse effects, ; Peptides, adverse effects, ; Protein Precursors, adverse effects,
Published: September 1, 1995 Show citation