Vnitr Lek 1993, 39(12):1181-1184
[Calcium and hypertension].
- Interní klinika 2. LF UK, FN Pod Petrínem, Praha.
Epidemiological, metabolic and intervention studies provided evidence of the interrelationship of calcium and high blood pressure. Patients with essential hypertension and low renin levels respond by a rise of blood pressure to administration of salt, while the pressure declines after calcium administration. Patients with a high renin activity are less sensitive to salt and calcium. The mentioned findings are probably associated with an impaired calcium transmission through the cellular membrane; the structural background of the phenomenon is not known so far. An important finding is the favourable therapeutic effect of calcium channel blockers in hypertonic patients with a low renin activity and conversely a greater effect of inhibitors of the angiotensin convertin enzyme in patients with a high renin level.
Keywords: Blood Pressure, physiology, ; Calcium, physiology, ; Humans; Hypertension, metabolism, ; Renin, blood,
Published: December 1, 1993 Show citation