Vnitr Lek 1993, 39(12):1157-1163
[Primary chronic glomerulonephritis with nephrotic syndrome. Treatment with prednisone and cyclophosphamide].
- II. interní klinika 1. LF UK, Praha.
Klíčová slova: Adult; Chronic Disease; Cyclophosphamide /administration & dosage/; Drug Therapy, Combination; Glomerulonephritis, Membranoproliferative /complications/; Glomerulonephritis, Membranous /complications/; Humans; Middle Aged; Nephrotic Syndrome /complications/; Prednisone /administration & dosage/
The authors present their long standing experience with immunosuppressive treatment of patients with nephrotic syndrome associated with primary chronic membranous, mesangioproliferative and mesangiocapillary glomerulonephritis. Of a total of 127 patients 99 were treated with prednisone and cyclophosphamide and 28 with cyclophosphamide only. Clinical remission developed in 89 patients (70%). Remissions developed independently on morphological findings and initial proteinuria, but more frequently in patients with a still normal glomerular filtration. In combined immunosuppression 77% of the treated patients developed remission, while only 48% treated with cyclophosphamide alone. 88% of the patients survive an average period of 10 years. From the investigation it is apparent that long-term and early combined immunosuppression has a favourable impact on the course of primary chronic glomerulonephritis with nephrotic syndrome.
Zveřejněno: 1. prosinec 1993 Zobrazit citaci