Vnitr Lek 1992, 38(6):608-616

[A minimal model of insulin and glucose kinetics].

M Kvapil, P Stolba: I. interní klinika fakultní nemocnice v Motole, Praha.

Klíčová slova: Blood Glucose, metabolism, ; Glucose Tolerance Test; Humans; Insulin, administration & dosage, ; Models, Biological

The minimal model of insulin and blood sugar kinetics is a method the basis of which are two mathematical models describing the dynamic changes of plasma glucose and insulin concentration along with the beta-cell response to the rise of the blood sugar level during the intravenous glucose tolerance test with frequent collection of samples. By means of computer processing the following indices are evaluated: SI--insulin sensitivity, SG--efficacy of glucose, phi 1 and phi 2 describing the sensitivity of beta-cells for glucose. According to present knowledge it is a simple method with a satisfactory reproducibility and validity of assembled results, which is safe for the examined subject and unpretentious as regards apparatus. It makes it possible to evaluate the glucose and insulin relationship in their mutual dynamic relationship and to create specific modifications as well as the follow-up of other indicators.