Vnitr Lek 1991, 37(4):323-329

[Echocardiographic monitoring of treatment of mild hypertension using nifedipine].

I Oral, H Vizinová: Katedra chorob vnitrních I. LF UP Olomouc.

Klíčová slova: Blood Pressure, drug effects, ; Echocardiography; Humans; Hypertension, drug therapy, ; Male; Nifedipine, therapeutic use, ; Vascular Resistance, drug effects,

Forty men with hypertension and a BPd lower than 14.66 kPa (110 mmHg) were treated for six months with nifedipine, 30 x 10 mg, with echocardiographically controlled changes of the minute output of the heart and the peripheral vascular resistance at rest and during an isometric load. In the group a wide range of values of cardiac output and peripheral vascular resistance was recorded. In patients with a high peripheral vascular resistance (group B, n = 11) a substantially better therapeutic effect was proved than in patients with a low initial vascular resistance (group A, n = 20). Nifedipine is indicated in patient with a slow heart rate at rest which does not markedly change after an isometric load. In patients with a more rapid heart rate preparations from the group of beta-blockers are more suitable.