Vnitr Lek 1990, 36(11):1072-1080

[Cytogenetic study in multiple myeloma. I. Chromosome findings in 56 patients].

M Jarosová, V Scudla, K Indrák, M Kapustová: Oddĕlení klinické hematologie FNsP Olomouc.

Klíčová slova: Adult; Aged; Aged, 80 and over; Chromosome Aberrations; Female; Humans; Karyotyping; Male; Middle Aged; Multiple Myeloma, genetics,

The authors submit the results of cytogenetic examination of 56 patients with multiple myeloma. Chromosome changes were found in 25, i.e. 45% patients. Structural changes were found most frequently in chromosomes no. 1, 11 and 14, numerical changes in chromosomes 3, 4, 9, 11, 14, 16, 19, 21, 22, X and Y. Marker chromosomes were present above all in hyperdiploid mitoses. The authors did not detect a relationship of chromosome changes and the type of produced monoclonal immunoglobulin, nor a statistically significant difference in the frequency of chromosomal changes in treated and untreated patients. Hyperploidy and complex rearrangements of chromosomes were observed mainly during progression of the disease. In three of four patients with developed secondary plasmocellular leukaemia the authors found a chromosomal change 14q+, in two as a result of translocation 11/14.

Keywords: Adult; Aged; Aged, 80 and over; Chromosome Aberrations; Female; Humans; Karyotyping; Male; Middle Aged; Multiple Myeloma /genetics/

Zveřejněno: 1. listopad 1990 Zobrazit citaci

Jarosová M, Scudla V, Indrák K, Kapustová M. [Cytogenetic study in multiple myeloma. I. Chromosome findings in 56 patients]. Vnitr Lek. 1990;36(11):1072-1080.

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