Vnitr Lek 1990, 36(7):633-638

[Echocardiographic control of treatment of mild hypertension with trimepranol].

I Oral, H Vizinová: Katedra chorob vnitrních I., LF UP Olomouc.

Klíčová slova: Adult; Blood Pressure, drug effects, ; Echocardiography; Humans; Hypertension, drug therapy, ; Male; Metipranolol, therapeutic use, ; Middle Aged; Vascular Resistance, drug effects,

Forty men with hypertension, diastolic BP lower than 14.66 kPa, were treated for six months with Trimepranol, 10 mg three times per day, with echocardiographic checking of changes of the cardiac minute output and the peripheral vascular resistance at rest and during an isometric load. In patients with a low baseline vascular resistance (group A, n = 20) a substantially better therapeutic effect was recorded than in patients with a markedly elevated peripheral resistance (group B, n = 11). Trimepranol is indicated in patients with a higher heart rate at rest and with a significant increase of the latter during isometric loading tests.