Vnitr Lek 1990, 36(1):70-74

[The effect of quinidine on digoxin plasma levels after discontinuation of digoxin therapy].

I Markuljak, J Květenský, V Licko, J Dvorský, S Funiak, V Záhradný: I. Interná klinika Lekárskej fakulty Univerzity Komenského Martin.

Klíčová slova: Arrhythmias, Cardiac, blood, ; Digoxin, administration & dosage, ; Drug Interactions; Female; Humans; Male; Middle Aged; Quinidine, pharmacology,

The authors submit a report on the effect of quinidine on plasma digoxin. The investigation was made in 20 patients wit supraventricular dysrhythmia. After initial digoxin treatment they proceeded with quinidine six hours after the last digoxin dose. Although they did not administer digoxin, the digoxin level increased during quinidine treatment in the course of 12 hours from 2.4 +/- 1.6 ng/ml to 3.8 +/- 12.4 ng/ml. The authors draw attention to the importance of following up digoxin levels in the mentioned drug combination which is supposed to prevent serious complication caused by possible digoxin intoxication.

Keywords: Arrhythmias, Cardiac /blood/; Digoxin /administration & dosage/; Drug Interactions; Female; Humans; Male; Middle Aged; Quinidine /pharmacology/

Zveřejněno: 1. leden 1990 Zobrazit citaci

Markuljak I, Květenský J, Licko V, Dvorský J, Funiak S, Záhradný V. [The effect of quinidine on digoxin plasma levels after discontinuation of digoxin therapy]. Vnitr Lek. 1990;36(1):70-74.

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