Vnitr Lek 1990, 36(1):45-51

[Electrophysiologic effects of orally administered amiodarone].

M Pleskot, V Pidrman, P Tilser: II. Katedra interních oborů, farmakologie a lékarské biochemie lékarské fakulty Univerzity Karlovy, Hradec Králové.

Klíčová slova: Administration, Oral; Adult; Aged; Amiodarone, administration & dosage, ; Bundle of His, drug effects, ; Electrocardiography, drug effects, ; Female; Humans; Male; Middle Aged

The authors made an invasive electrophysiological examination of the heart before and after administration of amiodarone by the oral route in 18 patients (15 men and 3 women). Amiodarone was administered in maintenance doses of 200 or 400 mg/day for 3 to 13 months (mean 4.7 months). Comparison of values revealed a significant protraction of R-R, P-Q and QRS intervals on the surface ECG. A-H and H-V intervals on the electrogram of the bundle of His as well as effective refractory periods of the ventricular myocardium were significantly protracted. During high-frequency stimulation of the atria the frequency at which an a-v block grade II type I develops declined. No significant changes developed in Q-Tc intervals on the surface ECG, the PA-A on the electrogram of the bundle of His and in the corrected recovery period of the s-a node.