Vnitr Lek 1989, 35(12):1151-1157

[Blood group Du].

M Hrubisko, D Cupaníková, L Ceizelová, D Pavlíková

Klíčová slova: Blood Grouping and Crossmatching; Humans; Rh-Hr Blood-Group System, immunology,

When examining blood group D, sensitive methods must be used which will detect false Du as D positive. When these methods are used the incidence of true Du is low, 1-2 pro mille. Moreover Du positive erythrocytes are practically not immunogenic, they may only be able to stimulate a secondary immune response, as easily revealed during antibody screening and during cross-matching. Their immunoreactivity is also low, a passively administered anti-D antibody does not eliminate them from the circulation. The clinical impact of true Du is therefore doubtful. There are also doubts as to the practical value of examination of Du. The authors submit their views on different clinical situations which concern donors and recipients of blood transfusions, pregnant women and neonates.