Vnitr Lek 1989, 35(10):1025-1032

[Acute myocardial infarct and the kinetics of creatine kinase].

J Sochman, J Fabiían, M Englis, A Belán

Klíčová slova: Coronary Vessels, pathology, ; Creatine Kinase, blood, ; Humans; Kinetics; Myocardial Infarction, enzymology, ; Myocardium, pathology,

The authors criticize contemporary views on creatine kinase kinetics in relation to the patency or occlusion of the coronary artery in the area of the infarction focus. In the investigation proper the time needed to achieve the peak plasma creatine kinase activity after the onset of infarction pain in patients with necroses in different areas of the left ventricle is assessed. Although the interpretation of the observed phenomenon is not clear so far, this finding makes the informative value of the hitherto used time parameter of the kinetics of this enzyme doubtful, in particular in thrombolytic treatment of myocardial infarction. In practice it is thus not possible to evaluate the restored patency of the artery to the necrotic focus on the basis of the above parameter.