Vnitr Lek 1989, 35(9):913-920
[Maximal dilatation of the coronary bed using dipyridamole in the diagnosis of coronary insufficiency].
Klíčová slova: Coronary Circulation, drug effects, ; Coronary Disease, diagnosis, ; Coronary Vessels, drug effects, ; Dipyridamole, pharmacology, ; Humans; Vasodilation, drug effects,
The authors give an account of the mechanism of action of dipyridamole. Via adenosine it produces selective and maximal vasodilatation of resisting coronary vessels in the non-ischaemic area. Thus redistribution of the blood flow from the ischaemic to the non-ischaemic portion of the heart muscle occurs along with clinical and electrocardiographic manifestations of cardiac angina which can be used for its diagnosis. The pharmacological dipyridamole test makes detection of myocardial ischaemia possible in a fundamentally different way as compared with other loading tests. The authors mention pharmacodynamic, metabolic, haemodynamic and associated phenomena of the action of dipyridamole and the mechanism of the opposite effect of aminophylline and nitroglycerin.
Keywords: Coronary Circulation /drug effects/; Coronary Disease /diagnosis/; Coronary Vessels /drug effects/; Dipyridamole /pharmacology/; Humans; Vasodilation /drug effects/
Zveřejněno: 1. září 1989 Zobrazit citaci