The authors investigated the therapeutic results in gastroduodenal ulcers in 96 patients treated with Gastrozepin (Slovakofarma), using daily doses of 75 mg combined with antacids. The examinations were made by means of a videogastroscope of Welch-Allyn Co. with subsequent control after four weeks, and if the ulcer was not healed, after two-week intervals. During the first examination they recorded the size of the ulcer and during check-up examinations the stage of healing. In a group of 51 men with a mean age of 44.4 years the incidence of duodenal ulcers was 29 cases (59.6%) and gastric ulcers 22 cases (43.1%). In a group of 45 women with a mean age of 51.4 years duodenal ulcers were detected in 24 (53.3%) and gastric ulcers in 21 (46.7%). After one-month treatment of 53 duodenal ulcers 44 (83%) healed by a scars. Healing of small and medium sized defects was excellent, they healed in 93.6%, while large defects only in 33.3%. Of 43 gastric ulcers after one month treatment 31 healed (72.1%) by a scar. Small and medium-sized defects healed in 80.5% and large ones only in 28.6%. With the exception of one case all were in an advanced stage of healing with a tendency of complete healing with scare formation.

Keywords: Adult; Antacids /administration & dosage/; Drug Therapy, Combination; Female; Gastroscopy; Humans; Male; Middle Aged; Peptic Ulcer /drug therapy/; Pirenzepine /administration & dosage/