Vnitr Lek 2025, 71(8):484-488

Endocrine disruptors and diabetes mellitus

Michaela Svojtková, Lucie Kolátorová, Jana Vítků
Endokrinologický ústav, Oddělení steroidů a proteofaktorů, Praha

The incidence of diabetes mellitus of all types has been increasing in recent years. At the same time, the number of anthropogenic chemicals in the environment that can influence the endocrine system is increasing. These substances are called endocrine disruptors (EDs) and their effects on endocrine-active organs are intensively studied. The relationship between ED and diabetes mellitus is a current topic of research. This review presents the current state of knowledge about the role of ED in all types of diabetes and the possible late consequences of their exposure during development. It also briefly discusses a basic overview of endocrine disruptors, the current state of legislation and the possibilities for preventing ED exposure.

Keywords: bisphenols, diabetes mellitus, endocrine disruptors, late effects, parabens, phthalates.

Accepted: November 26, 2025; Published: December 15, 2025  Show citation

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Svojtková M, Kolátorová L, Vítků J. Endocrine disruptors and diabetes mellitus. Vnitr Lek. 2025;71(8):484-488.
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References

  1. Diamanti-Kandarakis E, Bourguignon JP, et al. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr rev. 2009;30:293-342 Go to original source...
  2. Bergman Å, Heindel JJ, Jobling S, et al. State of the science of endocrine disrupting chemicals 2012: an assessment of the state of the science of endocrine disruptors prepared by a group of experts for the United Nations Environment Programme and World Health Organization. World Health Organization 2013. Go to original source...
  3. Dušková M, Kolátorová L, Stárka L. Endokrinní disruptory a diabetes mellitus. In Kvapil: Diabetologie 2018, Triton, Praha 2018:169-181.
  4. Kolátorová L, Vítků J, Dušková M, Stárka L. Endokrinní disruptory. DMEV 2018;21(2):120-127.
  5. https://echa.europa.eu/cs/home
  6. Welshons WV, Nagel SC, vom Saal FS. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology. 2006;147:S56-69. Go to original source...
  7. Eladak S, Grisin T, Moison D, et al. A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil Steril. 2015;103(1):11-21. Go to original source...
  8. European Commission. Commission adopts ban of Bisphenol A in food contact materials [Internet]. DirectorateGeneral for Health and Food Safety; 2024 Dec 19 [cited 2025924]. Available from: https://food.ec.europa.eu/food-safety-news-0/commission-adopts-ban-bisphenol-food-contact-materials-2024-12-19
  9. Saad N, Bereketoglu C, Pradhan A. Di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) alters transcriptional profiles, lipid metabolism and behavior in zebrafish larvae. Heliyon. 2021;7(9):e07951. Go to original source...
  10. Bledzka D, Gromadzinska J, Wasowicz W. Parabens. From environmental studies to human health. Environ Int. 2014;67:27-42. Go to original source...
  11. Jefferson WN, Padilla-Banks E, Newbold RR. Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant doses. Biol Reprod. 2005;73:798-806. Go to original source...
  12. Howard SG, Lee DH. What is the role of human contamination by environmental chemicals in the development of type 1 diabetes? J Epidemiol Community Health 2012; 66(6):479-81. Go to original source...
  13. Bodin J, Bølling AK, Becher R, et al. Transmaternal bisphenol A exposure accelerates diabetes type 1 development in NOD mice. Toxicol Sci 2014; 137(2):311-23. Go to original source...
  14. Dufour P, Pirard C, Lebrethon MC, et al. Associations between endocrine disruptor contamination and thyroid hormone homeostasis in Belgian type 1 diabetic children. Int Arch Occup Environ Health. 2023;96(6):869-881. Go to original source...
  15. Predieri B, Bruzzi P, Bigi E, et al. Endocrine Disrupting Chemicals and Type 1 Diabetes. Int J Mol Sci. 2020;21(8):2937. Go to original source...
  16. Keskesiadou GN, Tsokkou S, Konstantinidis I, et al. Endocrine-Disrupting Chemicals and the Development of Diabetes Mellitus Type 1: A 5-Year Systematic Review. Int J Mol Sci. 2024;25(18):10111. Go to original source...
  17. Chevalier N, Fénichel P. Endocrine disruptors: new players in the pathophysiology of type 2 diabetes? Diabetes Metab. 2015;41(2):107-15. Go to original source...
  18. Velmurugan G, Ramprasath T, Gilles M, et al. Gut Microbiota, Endocrine-Disrupting Chemicals, and the Diabetes Epidemic. Trends Endocrinol Metab 2017;28(8):612-625. Go to original source...
  19. He K, Chen R, Xu S, et al. Environmental endocrine disruptor-induced mitochondrial dysfunction: a potential mechanism underlying diabetes and its complications. Front Endocrinol (Lausanne). 2024;15;15:1422752. Go to original source...
  20. González-Casanova JE, Pertuz-Cruz SL, Caicedo-Ortega NH, et al. Adipogenesis Regulation and Endocrine Disruptors: Emerging Insights in Obesity. Biomed Res Int. 2020;2020:7453786. Go to original source...
  21. Dalamaga M, Kounatidis D, Tsilingiris D, et al. The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies. Int J Mol Sci. 2024;25(1):675. Go to original source...
  22. Alonso-Magdalena P, Vieira E, Soriano S, Menes L, et al. Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring. Environ Health Perspect. 2010;118(9):1243-50. Go to original source...
  23. Yan D, Jiao Y, Yan H, et al. Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis. Environ Health. 2022;21(1):53. Go to original source...
  24. Kahn LG, Philippat C, Nakayama SF, et al. Endocrine-disrupting chemicals: implications for human health. Lancet Diabetes Endocrinol. 2020;8(8):703-718. Go to original source...




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