Vnitr Lek 2025, 71(1):8-13 | DOI: 10.36290/vnl.2025.001

Hyperuricemia and gouty arthritis

Jan Voříšek, David Suchý

Oddělení klinické farmakologie, FN Plzeň

Crystal-induced arthropathy is caused by the deposition of crystal deposits in joint structures. Most often in clinical practice we encounter the deposition of sodium urate crystals, which is the cause of gouty arthritis. Gouty arthritis in adulthood is one of the most common inflammatory joint disorders. Especially in the developed part of the world, where in recent years we have seen a trend towards an increase in this disease. The main risk factor for the development of gouty arthritis is hyperuricemia, i.e. a pathological increase in the level of uric acid in the blood. Gouty arthritis affects the quality of life of patients not only by significant pain, but also by a relatively close relationship to cardiovascular complications. In therapy, we use both pharmacological and non-pharmacological procedures. Control of the systemic risks of the disease must also be included in the comprehensive therapy.

Keywords: allopurinol, gouty arthritis, febuxostat, hyperuricemia.

Accepted: February 6, 2025; Published: February 18, 2025  Show citation