Epidemiologic data of hyperuricaemia prevalence in the conditions of primary care in Slovakia

Andrej Dukát, Peter Sabaka, Ján Gajdošík, Marjan Vrbnjak, Oliver Tlčimuka, Peter Gavorník, Ľudovít Gašpar, F. Šimko

Vnitr Lek 2015, 61(Suppl 5):7-11  

Hyperuricaemia represents nowaday the new risk factor for cardiovascular diseases. Prevalence data and its treatment in our patient's population are still missing. Literature data shows, that its prevalence differs in various populations significantly from 4 % up to 40 % with race and geographical means. In the hospital population its prevalence is about 7 % and represents the important predictor of hospital mortality, e.i with heart failure. From the Framingham data relative risk was estimated of 25 % for cardiovascular diseases, coronary heart disease and all-course mortality. From the epidemiologic survey Mirror Slovakia hyperuricaemia was evaluated...

Management of treatment in patients with neuroendocrine neoplasmas of digestive tract

Soňa Kiňová, Martina Kováčová, Martin Čaprnda, Michal Koreň

Vnitr Lek 2015, 61(Suppl 5):12-20  

Neuroendocrine neoplasmas are a form of cancer arising from cells of diffuse neuroendocrine system. They produce peptides or amines that act as hormones or neurotransmitters. Incidence of NENs is relatively low. Diagnostic work-up and treatment requires a multidisciplinary team approach. The aim of this study was an analysis of data from patients with well-differentiated neuroendocrine neoplasmas of gastrointestinal tract. The study included patients followed up from 1998 to 2013 with histologically confirmed well-differentiated digestive neuroendocrine neoplasm with low or intermediate malignant potential. 97 patients were included; 34 men (35.1 %)...

Specifics of using ambulatory blood pressure monitoring in the elderly

Ľudovít Gašpar, Ivan Balažovjech, Boris Krahulec

Vnitr Lek 2015, 61(Suppl 5):21-24  

Arterial hypertension is a chronic disease which represents a major risk factor for damage of cardiovascular system. Insufficient control of elevated blood pressure is associated with the development of target organ damage, increased cardiovascular morbidity and mortality with a adverse prognostic value. Using ambulatory blood pressure monitoring (ABPM) we can improve the overall management of elderly patients at which the prevalence of arterial hypertension is particularly high.

Arterial hypertension - multicirculus vitiosus vasorum

Peter Gavorník, Andrej Dukát, Ľudovít Gašpar, Naďa Hučková, Laura Slezáková, Katarína Kusendová, Gabriela Gubo, Denisa Medová, Xénia Faktorová, Eva Gavorníková

Vnitr Lek 2015, 61(Suppl 5):25-34  

Aim:The aim of this review is to address documents and a number of studies on hypertension published in the last years in order to assess their contribution to our expanding knowledge of arterial hypertension. Discussion:Arterial hypertension is not defined by symptoms and signs but by numbers of blood pressure values. Arterial hypertension is vascular disease (vascular risk factor) of many vascular diseases (atherosclerosis; arteriolosclerosis/arteriolonecrosis/arteriolocalcinosis; arterial thrombosis; arterial embolism; arterial thromboembolism; arterial dissection; complicated arterial aneurysm) and other. Conclusion:Arterial...

Hormonal changes in inflammatory bowel disease

Jana Kollerová, Tomáš Koller, Tibor Hlavatý, Juraj Payer

Vnitr Lek 2015, 61(Suppl 5):35-39  

Inflammatory bowel disease is often accompanied by extraintestinal manifestations due to a common autoimmune etiopathogenesis, chronic systemic inflammation, frequent nutrition deficits, and the treatment. Endocrine system changes belong to manifestations too. Interaction is mutual, Crohn's disease and ulcerative colitis cause functional and morphological changes of endocrine tissues. On the other hand the endocrine disorders negatively influence the course of bowel disease. In the article we analyze correlation of IBD with gonadal hormone production and fertility, with adrenal function, with the function and morphology of the thyroid, with growth...

Diagnostics of polycystic ovary syndrome

Ivica Lazúrová, Jana Figurová, Zora Lazúrová

Vnitr Lek 2015, 61(Suppl 5):40-44  

Polycystic ovary syndrome (PCOS) is the most frequent endocrinopathy among women of reproductive age and the most frequent cause of menstruation cycle disorders. It is marked by a hyperandrogenic state (clinical and/or biochemical) and ovulatory dysfunction (anovulation and/or ultrasonographic finding of polycystic ovaries), which are also criteria for its diagnosis according to Androgen Excess and PCOS Society. The syndrome has multiple phenotypic expressions, among them besides the above characteristics also a metabolic syndrome, primarily obesity and insulin resistance. Diagnosing of PCOS may be rather exacting in clinical practice and it remains...

Non usual cases of hypoglycaemia - hypoglycaemia factitia

Michal Mokáň, Peter Galajda, Marián Mokáň

Vnitr Lek 2015, 61(Suppl 5):45-49  

Hypoglycaemia factitia means also in recent time serious diagnostic and therapeutic problem in medical clinical practice, whereby often repeating episodes of serious hypoglycaemia in patients with diabetes mellitus, but also in patients without diabetes mellitus could be very difficult do resolve. First unsuccessful diagnosis implicit from wrong chose of examination algorithm, can lead to unidentified surgical interventions as are laparotomy and pancreatectomy, respectively. Hypoglycaemia factitia is considered to be one of many manifestations of so called Münchhausen's syndrome for that is typical acting of diabetic patient with goal to intentionally...

Is iron important in heart failure?

Ján Murín, Miroslav Pernický

Vnitr Lek 2015, 61(Suppl 5):50-55  

Iron deficiency is a frequent comorbidity in a patient with chronic heart failure, and it associates with a worse prognosis of that patient. Mainly worse quality of life and more rehospitalizations are in these iron deficient patients. Iron metabolism is rather complex and there is some new information concerning this complexity in heart failure. We distinquish an absolute and a functional iron deficiency in heart failure. It is this deficit which is important and not as much is anemia important here. Prevalence of anaemia in heart failure is about 30-50 %, higher it is in patients suffering more frequently heart failure decompensations. Treatment...

Novel diagnostic and therapeutic procedures in diabetic nephropathy

Peter Ponťuch

Vnitr Lek 2015, 61(Suppl 5):57-62  

Epidemiological studies show increasing prevalence of diabetic nephropathy. Diabetic patients with chronic kidney disease are the biggest group from among patients on renal replacement therapy. Renal Pathology Society developed pathological classification of diabetic nephropathy. The cardinal biochemical diagnostic parameters are albuminuria and estimated glomerular filtration rate. European Renal Best Practice work group developed Clinical Practice Guideline on management of patients with diabetes and chronic kidney disease stage 3b or higher.

Are we to pay attention to factor XII deficiency?

Anna Remková, Milan Remko

Vnitr Lek 2015, 61(Suppl 5):63-66  

Severe coagulation factor XII (FXII) deficiency is a very rare, mysterious and not well known inherited condition. Unlike other coagulation factor deficiencies, it is totally asymptomatic. Surprisingly, it does not lead to abnormal bleeding, even with major surgical procedures. The explanation for the lack of bleeding manifestations is unknown. It is suggested, but unproven, that patients are not sufficiently protected from thrombosis. FXII deficiency is usually discovered by accident through a routine coagulation testing done prior to surgery. Since FXII plays an important role in clot formation during in vitro measurements, its deficiency causes...

Odhalenie pamätnej tabule profesorovi MUDr. Viliamovi Ganzovi, PhD., FACC, dňa 9. októbra 2014 v Košiciach

Miroslav Mydlík, Katarína Derzsiová

Vnitr Lek 2015, 61(Suppl 5):68-70  

Spomienka na pána profesora Ivana Ďuriša

Soňa Kiňová

Vnitr Lek 2015, 61(Suppl 5):3