Radiojod u nízkorizikového karcinomu štítné žlázy - editorial

Jiří Horáček

Vnitr Lek 2015, 61(9):755-757  

Cílená léčba chronické myeloidní leukemie u starších pacientů - editorial

Edgar Faber

Vnitr Lek 2015, 61(9):758-759  

Tyrozinkinázové inhibitory v léčbě starších pacientů s chronickou myeloidní leukemií - editorial

Daniela Žáčková

Vnitr Lek 2015, 61(9):760-761  

Chronická žilní onemocnění - nutnost přesnější diferenciace stavů k určení optimálního způsobu léčby - editorial

Debora Karetová

Vnitr Lek 2015, 61(9):762-764  

Kavální filtry v roce 2015 - komu, kdy a jak? - editorial

Jana Hirmerová

Vnitr Lek 2015, 61(9):765-766  

Stravování a kardiovaskulární onemocnění - dialogy a protimluvy - editorial

Jan Piťha

Vnitr Lek 2015, 61(9):767-768  

Draft of the best medical treatment in patients with low-risk thyroid cancer

Petr Vlček, Dagmar Nováková, Jan Vejvalka, Jaroslav Zimák, Martin Křenek, Květuše Vošmiková, Svatopluk Smutný, Petr Bavor, Jaromír Astl, Jindřich Lukáš

Vnitr Lek 2015, 61(9):769-777  

Introduction:The incidence of well-differentiated low-risk thyroid cancer have increased globally over the last three decades. Thyroid cancer treatment relates to a suitable surgical procedure and the use of adjuvant radioiodine therapy in selected patients. Evaluation of prognostic factors and risk stratification are critical for determining appropriate treatment. Survival of patients with low-risk thyroid cancer is excellent. Appropriate choice of medical treatment resulted in full recovery in most patients. Relapse risk increases with the size of the primary tumor, along with the findings of the risk factors in men. Methods and...

Secondary humoral immunodeficiency in patiens with systemic lupus erythematosus

Pavlína Králíčková, Eva Malá, Doris Vokurková, Ondřej Souček, Irena Krčmová, Zbyněk Hrnčíř

Vnitr Lek 2015, 61(9):778-784  

Introduction:Systemic lupus erythematosus (SLE) is a chronic autoimmune multisystem disease. The aim of our study was to clarify the frequency of decreased serum immunoglobulin levels in SLE patients. There were evaluated 799 results of serum immunoglobulin levels gained from 157 patients fulfilling revised ACR criteria in the retrospective study. Results:The immunoglobulin levels under the normal range were found in 29/157 (18.5 %) patients. The most frequent was isolated reduction of IgG 12/157 (7.6 %), two persons fulfilled criteria for selective IgA deficiency, and one case possible diagnosis of common variable...

Impact of age on the clinical response of patients with CML treated with imatinib

Petra Bělohlávková, Jaroslava Voglová, Jakub Radocha, Pavel Žák

Vnitr Lek 2015, 61(9):785-791  

Introduction:Treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKI) has significantly changed the survival of patients of all age categories. In our work, we have tried retrospectively to analyze a therapeutic response and toxicity of imatinib according to age of patients (≤ 60 years vs > 60 years). Patients have started treatment with imatinib in 2001-2013 in our department. The duration of treatment was at least 18 months. Patients and methods:The whole group contains 103 patients (52 women, 51 men) with a median age at diagnosis of CML 55 years (range 19-88 years). The first group includes...

The role of metabolic syndrome in gastroenterology

Petr Dítě, Jitka Přinosilová, Lenka Dovrtělová, Tomáš Kupka, Hana Nechutová, Bohuslav Kianička, Bohdana Břegová, Lumír Kunovský, Arnošt Martínek, Miroslav Souček

Vnitr Lek 2015, 61(9):792-798  

Goal:Metabolic syndrome and its components play an important part in the development of not only cardiovascular conditions, but also digestive and pancreaticobiliary system diseases. The aim of our study is to present a comprehensive overview of the diseases where metabolic syndrome is an inducing risk factor, or where it affects the course of the disease. Results:Metabolic syndrome is a significant risk factor of induction of gastroesophageal reflux and its complication, which is Barrett's esophagus. Metabolic syndrome was described as the disease closely linked to idiopathic intestinal inflammations, diseases of the biliary...

Usefulness of vena cava filters from clinicians view

Otto Mayer, Zdenka Poklopová

Vnitr Lek 2015, 61(9):799-804  

The indication for vena cava filters (VCF) in treatment of venous thromboembolism is still controversial. The presented overview should support the practical decisions. Beside of large volume of observational date there is only one study - PREPIC 1 - fulfilling requirements of prospective randomized design. During 8 years of follow up, pulmonary embolism (PE) was less frequent in the group with VCF than in the group without VCF, but at the cost of more frequent deep vein thrombosis (DVT). Other, but observational studies, showed similar results. Since last 10 years retrievable VCF are available. PREPIC 2 study was settled to prove, if use of retrievable...

Therapeutic potential of micronized purified flavonoid fraction (MPFF) of diosmin and hesperidin in treatment chronic venous disorder

Lukáš Hnátek

Vnitr Lek 2015, 61(9):807-814  

Chronic venous disorder (CVD) is a common illness with high incidence existing especially in Europe and North America. The main goal of micronized purified flavonoid fraction (MPFF) of diosmin and hesperidin is to eliminate the symptoms of CVD (venous pain, fatigue, etc). But MPFF of diosmin and hesperidin has good effectiveness for treatment of venous oedema and venous ulcer too. There are many papers that prove its effectiveness in the experiment and in the microcirculation too. The other indications for MPFF of diosmin hesperidin is hemorrhoidal disease and the accessory treatment of lymphedema. It is proved that this substance could be used as...

Dietary changes in relationship to risk factors and coronary heart disease mortality

Jiří Brát, Michal Vrablík, Otto Herber

Vnitr Lek 2015, 61(9):815-820  

Europe is a region, which is most severely affected by non-communicable diseases. Cardiovascular disease is the leading cause of disability and death. Complex interactions between diet, lifestyle, and lipoprotein metabolism significantly contribute to the development of atherosclerosis and its complications. Role of diet in prevention of coronary heart disease becomes sometime underestimated in comparison with pharmacological treatment. Coronary heart disease (CHD) mortality has declined substantially in the Czech Republic in the last decade of the 20^th century. Significant and positive dietary changes, mainly reduction of saturated fatty...

Myopathy in patients with Waldenström's macroglobulinemia. A case study and an overview of autoimmune expressions of type IgM monoclonal immunoglobulins

Zdeněk Adam, Jarmila Kissová, Luděk Pour, Marta Krejčí, Eva Ševčíková, Renata Koukalová, Zdeňka Čermáková, Marta Černá, Zdeněk Král, Jiří Mayer

Vnitr Lek 2015, 61(9):821-828  

In rare cases, monoclonal immunoglobulins bind to intrinsic antigens whereby causing autoimmune damage to the body. The text describes Waldenström's macroglobulinemia which was manifested by muscle pain and anemia. The female patient had suffered from back pain for about 3 years before she came to our clinic. In the last year pain in the muscles of the upper and lower extremities developed in addition to back pain. This led to the suspicion of polymyositis. However this was not confirmed by a special examination. The patient was diagnosed with clearly established infiltration of lymphoplasmacytic lymphoma and 10.8 g/l of type IgM monoclonal immunoglobulin...

František Kopřiva. Chronický kašel. Průvodce ošetřujícího lékaře

Martina Doubková

Vnitr Lek 2015, 61(9):829  

Jan Máca et al. ARDS v klinické praxi

Karel Cvachovec

Vnitr Lek 2015, 61(9):829-830  

Rudolf Kotas. Bolesti hlavy v klinické praxi

Jiří Mastík

Vnitr Lek 2015, 61(9):830  

Josef Veselka, Vilém Rohn a kolektiv. Kardiovaskulární medicína

Ján Murín

Vnitr Lek 2015, 61(9):831  

(Ne)očekávané výsledky studie EMPA-REG OUTCOME™

Jiří Slíva

Vnitr Lek 2015, 61(9):832  

Poznámka k diferenciální diagnostice hyponatremie

Otto Schück, Jiří Kříž, Miroslava Horáčková

Vnitr Lek 2015, 61(9):833-834  

Acute Leukemias XV, Biology and Treatment Strategies

Petr Lemež

Vnitr Lek 2015, 61(9):835-838