Vnitr Lek 2015, 61(9):792-798

The role of metabolic syndrome in gastroenterology

Petr Dítě^1,*, Jitka Přinosilová¹, Lenka Dovrtělová², Tomáš Kupka¹, Hana Nechutová³, Bohuslav Kianička³, Bohdana Břegová¹, Lumír Kunovský⁴, Arnošt Martínek¹, Miroslav Souček³

¹ Oddělení gastroenterologie, metabolizmu a výživy Interní kliniky LF Ostravské univerzity a FN Ostrava, přednosta doc. MUDr. Arnošt Martínek, CSc.

² Katedra podpory zdraví, Fakulta sportovních studií MU Brno, vedoucí katedry Mgr. Lenka Dovrtělová, Ph.D.

³ Gastroenterologické oddělení II. interní kliniky LF MU a FN u sv. Anny Brno, přednosta prof. MUDr. Miroslav Souček, CSc.

⁴ Chirurgická klinika LF MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Zdeněk Kala, CSc.

Goal:
Metabolic syndrome and its components play an important part in the development of not only cardiovascular conditions, but also digestive and pancreaticobiliary system diseases. The aim of our study is to present a comprehensive overview of the diseases where metabolic syndrome is an inducing risk factor, or where it affects the course of the disease.

Results:
Metabolic syndrome is a significant risk factor of induction of gastroesophageal reflux and its complication, which is Barrett's esophagus. Metabolic syndrome was described as the disease closely linked to idiopathic intestinal inflammations, diseases of the biliary tree and pancreas. Acute pancreatitis, both its development in obese individuals and the burden of its course, are in close correlation with metabolic syndrome, similarly as the course of chronic, mainly alcoholic pancreatitis. Study of non-alcoholic steatopancreatitis presents a challenge, most importantly with regard to the function of pancreatic B cells in obese individuals. Non-alcoholic hepatic steatosis and its forms may as much as lead to the stage of cirrhosis of the liver and they pose a risk of hepatocellular carcinoma. Metabolic syndrome was also described in a population study as a risk factor for carcinoma of the colon.


Summary:
Metabolic syndrome and its components present an important risk factor in relation to inducing some benign as well as malignant gastrointestinal and pancreaticobiliary diseases. A systemic approach to influencing the metabolic syndrome and its components is therefore one of the important approaches to influencing the development and course of not only cardiovascular conditions.

Keywords: gastrointestinal cancers; idiopathic intestinal inflammation; obesity; pancreatopathy; reflux disease; steatohepatitis metabolic syndrome

Received: February 17, 2015; Accepted: April 10, 2015; Published: September 1, 2015  Show citation