Acute myocardial infarction in young adults - what is wrong? - editorial

P. Toušek

Vnitr Lek 2012, 58(10):713-714  

Less invasive cardiac surgery approaches to treat ischemic heart disease - editorial

T. Vaněk

Vnitr Lek 2012, 58(10):715-716  

Visceral leishmaniasis - editorial

D. Sedláček

Vnitr Lek 2012, 58(10):717-718  

Festina lente! - editorial

J. Hradec

Vnitr Lek 2012, 58(10):719-720  

Acute myocardial infarction in young patients - severe failures in the system of acute and secondary care

G. Dostálová, J. Bělohlávek, L. Vítek, L. Muchová, M. Škvařilová, D. Karetová, K. Jirátová, J. Kvasnička, D. Vondráková, O. Toman, A. Linhart

Vnitr Lek 2012, 58(10):721-729  

Introduction:The incidence of cardiovascular (CV) diseases and acute myocardial infarction (AMI) in Czech Republic is declining. In spite of this in a proportion of patients AMI occurs in young age. The aim of our project was to assess the character of risk factors, precipitating diseases and the quality of care in young AMI survivors. Methods:We included 132 patients (97 men and 35 women) in whom AIM with ST elevations occurred before age of 45 years in men and age of 50 years in women. Several results were compared to a control group composed of 84 healthy volunteers of comparable age. We assessed the course of the disease,...

Is there a relationship between inflammatory markers, oxidative stress and postoperative atrial fibrillation?

F. Sabol, M. Jakubová, P. Mitro, A. Bomba, A. Chmelárová, D. Petrášová, B. Stančák, V. Nagy, P. Török, A. Šebová

Vnitr Lek 2012, 58(10):730-734  

Introduction:Atrial fibrillation (AF) is one of the most common complications following heart surgery. The aim of this work was to verify the relationship between inflammatory markers, oxidative stress and postoperative arrhythmia. Methods:45 patients with ischemic heart disease (12 women and 33 men, mean age 62.3 ± 9.4 years) underwent surgical myocardial revascularization. The extracorporeal circulation (ECC) was used in 30 patients, without ECC was 15 patients. During the first 3 postoperative days was determining the incidence and duration of the AF, laboratory markers of inflammation (CRP, leukocytes, TNFα),...

Sarcoidosis - diagnostics, prognosis and therapy. A retrospective analysis

M. Doubková, I. Binková, J. Skřičková

Vnitr Lek 2012, 58(10):735-742  

Sarcoidosis is systematic granulomatous disease of unknown etiology which can affect any organ. Sarcoidosis belongs to diseases called interstitial lung diseases. Our study is a retrospective analysis of 169 patients (100 females and 69 males), whom we diagnosed sarcoidosis at our pulmonary department in years 2005-2010. Aim of the analysis was to find out prognostic factors and to describe the course of disease. Median age of sarcoidosis patients was 48 years (20-79). Females : males ratio was 1.5 : 1. Non smoker : smoker (or former smoker) ratio was 2.2 : 1. Familial occurrence was observed in 4 patients (2.4%). At diagnosis, stage 0 was present...

Diagnosis and treatment of arterial hypertension. 2012 Guidelines of the Czech Hypertension Society

J. Filipovský, J. Widimský jr, J. Ceral, R. Cífková, K. Horký, A. Linhart, V. Monhart, H. Rosolová, J. Seidlerová, M. Souček, J. Špinar, J. Vítovec, J. Widimský

Vnitr Lek 2012, 58(10):785-801  

Vitamin C and its physiological role with respect to the components of the immune system

D. Holmannová, M. Koláčková, J. Krejsek

Vnitr Lek 2012, 58(10):743-749  

Vitamin C is a water soluble micronutrient commonly found in our diet which orchestrates the function of both innate and adaptive immune system, influencing both cellular and humoral immune responses. Vitamin C inhibits excessive activation of the immune system to prevent tissue damage, but also supports antibacterial activity, stimulates NK cells and differentiation of Th0 subset into Th1 characterized by interferon γ production. In addition, vitamin C interferes with the synthesis of proinflammatory cytokines, or with the expression of adhesive molecules. Moreover, vitamin C as an antioxidat protects the immune cells against intracellular ROS...

Hypoglycaemia - a phenomenon over which modern diabetology manages to prevail

Š. Svačina

Vnitr Lek 2012, 58(10):751-754  

Hypoglycaemia is considered to be the most significant complication when treating diabetes. The most important is its association with cardiovascular risk. Rigorous self-monitoring, lifestyle changes and the use of insulin analogues reduce the risk significantly in type 1 diabetes patients. Combined insulin and incretin therapy appears to be useful. Individualized therapy and incretin treatment in particular represent considerable risk reduction in type 2 diabetes patients. It is crucial to change therapy in a patient who underwent hypoglycaemia. Modern antidiabetic therapy helps to surmount the risk of hypoglacaemia and it is possible at any stage...

AII antagonists (candesartan and irbesartan) in the treatment of cardiovascular diseases

J. Špinar, J. Vítovec

Vnitr Lek 2012, 58(10):755-760  

Treatment of hypertension with angiotensin II receptor antagonists (AIIA) was first limited to diabetics and patients with microalbuminuria. So far, results of several large clinical trials with AIIAs were published, confirming significant renoprotective effect of these agents compared to placebo (RENAAL and IRMA), amlodipin (MARVAL and IDNT) and a combination of ACEI and AIIA (CALM). In 2002, results of 2 large comparator studies in hypertension were published: LIFE - Losartan Intervention For Endpoints and SCOPE - the Study on COgnition and Prognosis in Elderly hypertensives. In 2003, a series of the CHARM studies involving patients with heart failure...

Dabigatran etexilate in clinical practice for prevention of thromboembolic events in patients with atrial fibrillation

M. Táborský, P. Heinc, Y. Hrčková

Vnitr Lek 2012, 58(10):769-777  

Dabigatrane is the first new generation antiacoagulant that at a dose of 150 mg twice daily was, in the RE-LY study, more effective in cerebrovascular event and systemic embolisation prevention than well-controlled warfarin and had comparable or better safety profile than well-controlled warfarin. The 110 mg twice daily dose showed comparable efficacy and superior safety against warfarin. Crucial and unique among modern anticoagulants is its ability to significantly reduce ischemic as well as hemorrhagic CVEs at a dose of 150 mg twice daily. In addition, dabigatran significantly facilitates management of patients with atrial fibrillation as it does...

Febrile pancytopenia and hepatosplenomegaly as leading symptoms of visceral leishmaniasis

P. Polák, R. Svoboda, P. Kubáčková, Y. Brychtová, A. Panovská, E. Nohýnková, P. Husa, M. Freibergerová, R. Pařízková, M. Šnelerová, M. Pýchová, J. Kamelander

Vnitr Lek 2012, 58(10):761-764  

The authors present a case report of a patient with febrile pancytopenia, hepatosplenomegaly and weight loss as main symptoms of visceral leishmaniasis. Standard treatment regimen with amphothericin B led to relapse of the disease after several weeks. The definitive cure of the disease was achieved with cytostatic miltefosin (Impavido^©), which is not registered in the Czech Republic. The aim of this article is to point out this imported protozoan infection and its basic clinical and laboratory features.

High suspicion of hearth disease gained from taking the case history must not controvert negative results of some medical examination - experience outpatient internist

H. Slámová

Vnitr Lek 2012, 58(10):765-767  

We report the case of a patient having atypical chest pain and difficult to breathe. The cardiac gated SPECT had insignificant result in compare with high positive results of coronary artery calcium score and coronarography.

Effect of ivabradin on heart rate, left ventricular function a NT-proBNP concentration in patients with systolic chronic heart failure - case reports

F. Málek

Vnitr Lek 2012, 58(10):779-783  

Ivabradin is indicated in patients with compensated chronic heart failure and sinus rhythm with resting heart rate ≥ 75 beats per minute despite maximal tolerated beta-blocker dose. Three case reports show favourable effect of ivabradin therapy on heart rate, reverse cardiac remodeling and B-type natriuretic peptide concentration in patients with systolic heart failure.

Vildagliptin v léčbě pacientů s diabetes mellitus 2. typu: co je nového?

M. Haluzík

Vnitr Lek 2012, 58(10):803  

Prehlásenie nového výboru Slovenskej internistickej spoločnosti (Novinky ze Slovenské internistické společnosti)

prof. MUDr. Ivica Lazúrová, FRCP, CSc., doc. MUDr. Soňa Kiňová, CSc., prof. MUDr. Juraj Payer, CSc.

Vnitr Lek 2012, 58(10)

Oznámení o konání XXXII. Dnů mladých internistů (Oznámení schůzí)

prof. MUDr. Josef Zadražil, CSc.

Vnitr Lek 2012, 58(10)

Základy moderní pneumoonkologie (Z odborné literatury)

doc. MUDr. František Salajka, CSc.

Vnitr Lek 2012, 58(10)

Spasticita a její léčba (Z odborné literatury)

MUDr. Blanka Mičánková Adamová, Ph.D.

Vnitr Lek 2012, 58(10)