Diagnostické metody k predikci respondentů srdeční resynchronizační terapie - editorial

J. Vlašínová

Vnitr Lek 2012, 58(1):5-6  

Diagnóza nemoci z ukládání lehkých řetězců imunoglobulinů (LCDD) v bioptické praxi - editorial

E. Honsová

Vnitr Lek 2012, 58(1):7-10  

Septický šok v důsledku infekční endokarditidy stimulačního systému implantabilního kardioverter-defibrilátoru - editorial

J. Schildberger

Vnitr Lek 2012, 58(1):11-12  

The importance of contractile reserve in patients with resynchronization therapy

P. Murín, P. Mitro, G. Valočik, B. Stančák

Vnitr Lek 2012, 58(1):13-17  

Introduction:Contractile reserve of the myocardium is a strong prognostic factor in patients with heart failure. The presence of a significant amount of myocardial fibrosis might lead to insufficient response to resynchronization therapy We assumed that pre-implantation examination of global contractile reserve will allow prediction of the response to resynchronization treatment. Methods:25 symptomatic patients (NYHA III) with severe systolic dysfunction [ejection fraction (EF) 28.9 ± 6.9%] with signs of electric asynchrony (QRS ≥ 120 ms) went through dobutamine echocardiography prior to resynchronization treatment....

A detailed study of colon polyps

J. Špičák, M. Beneš, T. Hucl, P. Štirand, P. Drastich, P. Wohl, D. Kamenář, M. Kliment, E. Kundratová, O. Urban, J. Pintová, J. Pícha, Š. Suchánek, V. Želízko, M. Štefanová, M. Řehoř, V. Nosek, M. Zavoral

Vnitr Lek 2012, 58(1):18-23  

Introduction, study aim:Colorectal carcinoma is one of the most frequent malignancies. Most frequently, neoplasms, including malignant precursors, are in the form of polyps, although these might be of a non-tumour origin. The aim of this prospective multicentre study was to provide an overview of coloscopic identification and biological nature of polyps. Results:3,400 consecutive coloscopies performed between 2009 and 2010 were analyzed. At different centres, the top of the cecum was reached in 89% to 93% and terminal ileum in 73% to 87% of cases. In the above 40 age group, 26.6% were screening coloscopies. The mean age of...

A recommended approach to evaluate cardiovascular risk and to prevent cardiovascular diseases and type 2 diabetes mellitus in women with polycystic ovary syndrome

J. Vrbíková, M. Fanta, T. Pelikánová, J. Škrha, J. Marek

Vnitr Lek 2012, 58(1):56-57  

Polycystic ovary syndrome is one of the most common endocrinopathy in women of fertile age. It is commnoly accompanied by an increased occurence of cardiovascular risk factors. This association led to a consensus statement of Androgen Excess Society for screening of cardiovascular risk factors. We present the recommendations of Czech Endocrine and Czech Diabetological Societies for the screening and primary prevention of cardiovascular diseases and diabetes mellitus.

Endocrine changes in liver disease

J. Kollerová, T. Koller, J. Payer

Vnitr Lek 2012, 58(1):24-30  

Liver diseases have an influence on function and morphology of all endocrine glands. Knowledge of these specific changes is important in correct interpretation of pathological clinical and laboratory hormonal symptoms and signs induced by liver disease. We analyze the influence on the thyroid, bone metabolism, adrenocorticotropic axis, gonadal hormones, prolactin and growth hormone.

Common, standardized and recommended approaches in the diagnosis and monitoring of paroxysmal nocturnal haemoglobinuria using flow cytometry

I. Marinov, A. Luxová, V. Tkáčová, D. Mikulenková, J. Čermák, P. Cetkovský

Vnitr Lek 2012, 58(1):31-37  

Paroxysmal nocturnal hemoglobinuria is an acquired clonal disease characterized by proliferation of stem cells, deficient of proteins linked to the membrane via glycophosphatidylinositol (GPI) anchors. PNH cell characterization by flow cytometry was introduced in 1986, since 1996 is considered as method of choice for PNH diagnosis. Flow cytometry PNH analysis is nowadays crucial for disease monitoring in terms of progression, regression, remission or response to therapy and screening for small PNH clones (< 1.0%) in patients with aplastic anemia or myelodysplastic syndrome. Flow cytometry is unfortunately still poorly standardized, there is a variety...

Light chain deposition disease

V. Ščudla, J. Minařík, T. Pika

Vnitr Lek 2012, 58(1):38-43  

The aim of the study is to put forward the recent knowledge about a relatively rare clinical condition caused by the deposition of immunoglobulin light chains κ or λ into the parenchyme of kidneys and other vital organs, leading to a progressive loss of their function with terminal organ failure. The paper focuses on the etiopathogenesis of light chain deposition disease, and the differentiation of idiopatic form of the disease from multiple myeloma associated conditions and other B lymphoproliferative disorders. We concentrate on the issue of clinical manifestation, contemporary diagnostic possibilities and differential diagnosis of the...

Modes of tissue blood perfusion assessment by microdialysis - a review of current knowledge

N. Cibiček

Vnitr Lek 2012, 58(1):44-51  

Microdialysis is a dynamically evolving method utilized for monitoring of tissue metabolism and barrier function, pharmacological studies and to estimate local blood perfusion in situ. The present review summarizes current knowledge of the last of the aforementioned applications on a characterization and comparison of two approaches used - microdialysis flow-indicator dilution technique and continuous metabolic monitoring. Currently, the use of metabolic indicators, which enable sensitive and complex evaluation of perfusion-induced changes in the tissue, is preferred. Despite the method's numerous advantages the measurement of tissue blood perfusion...

Hyponatraemia associated with the syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH) - options for treatment

M. Rudnay, P. Hrabčáková, I. Lazúrová

Vnitr Lek 2012, 58(1):52-55  

Hyponatremia is the most common electrolyte imbalance in outpatients and hospital inpatients and the syndrom of inappropriate secretion of antidiuretic hormone (SIADH) is one of the common causes of euvolemic hyponatremia. Recent studies showed significantly higher mortality and morbidity of hyponatriemic patients compared to normonatriemic controls. Moreover the morbidity and mortality of hyponatremic patients significantly increases in nontreated in comparison to those with the therapy. Clinical consequences of hyponatremia in SIADH could be devided according to stage of the disorder. The cerebral oedema with its symptoms (letargy, weakness, nausea,...

Septic shock due to infective endocarditis of stimulation system of implantable cardioverter-defibrillator

I. Porubčinová, Š. Porubčin, B. Stančák, M. Beňa, F. Sabol

Vnitr Lek 2012, 58(1):58-61  

We present a case of a 60-year old patient hospitalized at the Department of Infectious Diseases and Travel Medicine, Medical faculty of UPJS and L. Pasteur's University Hospital in Kosice with suspected gastroenteritis. The patient was admitted to an intensive care unit because of the signs of septic shock. Within one hour from admission, the patient was administered early goal directed therapy for septic shock. Subsequently, infectious endocarditis of stimulation electrodes and tricuspid valve was identified as the origin of the infection. The stimulation system was then explanted from a stabilized and afebrile patient at the Department of cardiac...

Lenalidomide induced therapeutic response in a patient with aggressive multi-system Langerhans cell histiocytosis resistant to 2-chloro-deoxyadenosine and early relapsing after high-dose BEAM chemotherapy with autologous peripheral blood stem cell transplantation

Z. Adam, Z. Řehák, R. Koukalová, P. Szturz, M. Krejčí, L. Pour, L. Zahradová, M. Moulis, R. Kodet, T. Nebeský, M. Brejcha, Z. Adamová, R. Hájek, J. Mayer

Vnitr Lek 2012, 58(1):62-71  

Adult Langerhans cell histiocytosis (LCH) usually follows a favorable course. Very rarely, however, multi-system (multi-organ) LCH difficult to manage either with traditional first line treatment (vinblastine, mercaptopurine, prednisone or etoposide) or 2-chlorodeoxyadenosine occurs. In these patients, other treatment modalities have to be used. We describe a patient with LCH manifesting with generalized lymphadenopathy and infiltrating the pulmonary parenchyma and skin. The disease activity was always associated with B-symptoms (weight loss, subfebrile states, night sweats). Histological investigations repeatedly showed higher proliferation activity...

Hyponatremia - carbamazepine medication complications

I. Dedinská, V. Maňka, I. Ságová, A. Klimentová, P. Makovický, J. Polko, J. Sadloňová, M. Mokáň

Vnitr Lek 2012, 58(1):72-75  

Hyponatremia can be defined like the low sodium concentration, lower that 135 mmol/l. It becomes really serious when the concentration is lower than 120 mmol/l. The most frequent causes of hyponatremia are: the extrarenal loss (GIT, skin, bleeding, sequestration), the renal loss (diuretics, nephritis with the salt loss, osmotical diuresis, the Addison disease), hypothyroidism, the lack of glucocorticoids, emotional stress, pain, pseudohyponatremia (incorrect taking, dyslipoproteinemia). There is fatigue, exhaustion, headache and vertigoes dominating in the clinical record file. By the deficit increasing a patient becomes delirious, comatose even with...

50-ročná publikačná činnosť v časopise Vnitřní lékařství

M. Mydlík, K. Derzsiová

Vnitr Lek 2012, 58(1):76-79  

Speciální chirurgie. 3. rozšířené a přepracované vydání (Z odborné literatury)

Jiří Vokurka

Vnitr Lek 2012, 58(1)

Nefropatie v utrazvukovém a histologickém obraze (Z odborné literatury)

doc. MUDr. František Záťura, Ph.D.

Vnitr Lek 2012, 58(1)

Erektilní dysfunkce a jejich léčba. Průvodce ošetřujícího lékaře (Z odborné literatury)

Jaroslav Zvěřina

Vnitr Lek 2012, 58(1)

Hirsutismus a jeho léčba. Průvodce ošetřujícího lékaře (Z odborné literatury)

MUDr. Karola Balšíková

Vnitr Lek 2012, 58(1)