Změna spektra supraventrikulárních tachyarytmií indikovaných ke katetrové ablaci - editorial

R. Lábrová

Vnitr Lek 2011, 57(6):523-528  

Brugada syndrom: syndrom vzácný, ale zákeřný - editorial

M. Štengl

Vnitr Lek 2011, 57(6):529-530  

Primární jaterní karcinoid - editorial

V. Zamrazil

Vnitr Lek 2011, 57(6):531-532  

Impact of long-term glycemic control on changes of lipid profile in children and adolescents with 1 type diabetes mellitus

J. Kostolanská, V. Jakuš, Ľ. Barák, A. Staníková

Vnitr Lek 2011, 57(6):533-539  

Introduction:Abnormalities in lipid metabolism contribute significantly to the increased occurrence of cardiovascular events in individuals with T1DM compared to healthy subjects. Disorder of lipid metabolism in T1DM is heavily dependent on maintaining of blood glucose values near the physiological range. DCCT study confirmed that patients with well compensated diabetes have similar lipid spectrum to the healthy subjects one. Aims:We aimed to study relations of lipid profile parameters (cholesterol of high density HDL, cholesterol of low density LDL, total cholesterol - TC, triglycerides - TAG) to age, duration of T1DM (DD),...

The efficacy and safety of moxonidine in patients with metabolic syndrome (the O.B.E.Z.I.T.A. trial)

J. Krupička, M. Souček, K. Chroust

Vnitr Lek 2011, 57(6):541-545  

Introduction:Treatment with agents neutral to lipid metabolism but with a positive effect on glucose metabolism might significantly improve the long-term prognosis of patients with metabolic syndrome and hypertension. The aim of our non-interventional observational clinical study was to evaluate the safety of treatment with moxonidine and to assess changes to the metabolic syndrome-related laboratory parameters. Materials and methods:A total of 748 patients over 18 years of age (22-87; mean 59; median 60) were included in a 6-month evaluation (two 3-monthly study visits). There were slightly more female patients (n = 401,...

Long-term outcome of catheter ablation therapy of supraventricular tachyarrhythmias

P. Pařízek, L. Haman, H. Dostálová, J. Duda, J. Popelka

Vnitr Lek 2011, 57(6):546-550  

Aim:The aim of the article is presentation of our results and experiences with radiofrequency catheter ablation (CA) in the therapy of supraventricular tachyarrhythmias. Patients and methods:From 1996 to 2009, 1 485 patients underwent CA (total procedure number - 1 627). The group consist of 772 patients with paroxysmal atrioventricular nodal reentry tachycardia (AVNRT): 484 women, mean age 50.3 ± 16.4 years; 312 patients with atrioventricular reentry tachycardia (AVRT): 145 women, mean age 40.1 ± 14.9 years; 391 patients with typical atrial flutter (AF): 96 women, mean age 61.6 ± 11 years; and 64 patients...

Brugada syndrome

M. Bébarová

Vnitr Lek 2011, 57(6):551-560  

Brugada syndrome (BrS) is, along with the long QT syndrome, one of the most frequently diagnosed inherited arrhythmogenic syndromes. It is a primary electric heart disease manifested by ST segment elevations in the right precordial leads. BrS is responsible for more than 4% of all sudden deaths and at least 20% of sudden deaths in patients with structurally normal hearts. In 1998, the first mutations in the gene coding the structure of the cardiac sodium channel were identified in patients with BrS. Nowadays, several hundreds of mutations in at least 8 genes have been already associated with BrS. Functional consequences of many of these mutations on...

Seniors and cardiovascular medications

H. Matějovská Kubešová, P. Weber, H. Meluzínová, J. Matějovský

Vnitr Lek 2011, 57(6):561-570  

Authors analyze the situation in the therapy of cardiovascular diseases - unsatisfactory situation especially from the dyslipidaemia point of view. Different groups of medications are discussed and their risks for elderly patients. Angiotensin converting enzyme blockers and their influence on the endothelial dysfunction, but the risk of hyperpotassemia are showed. The risk of gastrointestinal bleeding during the treatment with antiagregants and anticoagulants, the risk of bradycardia in beta-blockade, possible interactions with other medications lowering the heart rate are discussed. Attention is paid to calcium channel blockers, diuretics and digoxin....

Infective endocarditis - crucial early diagnosis

J. Zarivnij, Y. Hrčková, M. Kaletová, D. Marek, M. Černá, M. Táborský

Vnitr Lek 2011, 57(6):572-575  

A 64-year old female patient with polymorbidity, including diabetes, was admitted to our clinic with a suspicion of silent myocardial infarction. However, no acute coronary lesion was subsequently confirmed. Transthoracal echocardiography performed just after the admission suggested infective endocarditis. The diagnosis was difficult due to a lack of collaboration by the patient who was disoriented and confused. Because of the suspicion of endocarditis, a therapy with antibiotics was started immediately and the diagnosis was confirmed by oesophageal echocardiography and heart MR performed after the patient was stabilized. An early diagnosis and an...

Successful treatment of Erdheim-Chester disease by 2-chlorodeoxyadenosine-based chemotherapy. Two case studies and a literature review

Z. Adam, R. Koukalová, A. Šprláková, Z. Řehák, L. Červinek, P. Szturz, M. Krejčí, L. Pour, L. Zahradová, M. Moulis, J. Prášek, R. Chaloupka, R. Hájek, J. Mayer

Vnitr Lek 2011, 57(6):576-589  

Introduction:Erdheim-Chester disease is an extremely rarely occuring condition and thus an optimal treatment is not known. Two new cases have been diagnosed in our centre in 2008 and 2009. Both patients had diabetes insipidus, B symptoms (subfebrile to febrile states) and pain in long bones of lower limbs. Case studies:Imaging showed high accumulation of fluorodeoxyglucose as well as Tc-pyrophosphate in long bones of lower as well as upper limbs, aortic wall thickening with periaortic fibrosis and perirenal fibrosis. In addition, one of the patients had multiple lesions in the brain. 2-chlorodeoxyadenosine 5 mg/m²...

Primary hepatic carcinoid

J. Plášek, M. Vybíralová, J. Dvořáčková, A. Petrušková, J. Sagan, M. Golián, V. Hrabovský, N. Petejová, A. Martínek

Vnitr Lek 2011, 57(6):590-594  

Primary hepatic carcinoid (PHC) is considered to be particularly sporadic diagnosis; in current world literature about 60 cases have been reported. Most of the patients present with abdominal pain, diarrhea, icterus, flush, weight loss or respiratory disease; even though the course of the disease might stay asymptomatic for a long time. An illuminating case of at presentation oligosymptomatic 72-year-old patient, which was after extensive examination based on OctreoScan and histological verification diagnosed to have generalized PHC, is reported. Paliative therapy with somatostatine analogues followed. At autopsy 8 months later the clinical diagnosis...

XVIII. kongres České internistické společnosti ČLS J. E. Purkyně - Praha, 25.-28. 9. 2011 (Sborník abstrakt)

Vnitr Lek 2011, 57(6)